Mitchell Lawrence Jones - Oct 6, 2025 Form 4 Insider Report for PALISADE BIO, INC. (PALI)

Role: Chief Medical Officer
Signature: /s/ Ryker Willie, Attorney-in-Fact
Stock symbol: PALI
Transactions as of: Oct 6, 2025
Transactions value $: $0
Form type: 4
Date filed: 10/8/2025, 05:41 PM
Previous filing: Sep 5, 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Jones Mitchell Lawrence	Chief Medical Officer	1902 WRIGHT PLACE, SUITE 200, CARLSBAD	/s/ Ryker Willie, Attorney-in-Fact	2025-10-08	0001993292

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PALI	Restricted Stock Units	Award	$0	+7.67M		$0.00	7.67M	Oct 6, 2025	Common Stock	7.67M		Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash.
F2	The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.