ABG Management Ltd. - Oct 22, 2025 Form 4 Insider Report for ProMIS Neurosciences Inc. (PMN)

Role: 10%+ Owner
Signature: ABG Management Ltd., By: /s/ Fan Yu, Director
Stock symbol: PMN
Transactions as of: Oct 22, 2025
Transactions value $: $0
Form type: 4
Date filed: 10/24/2025, 04:34 PM
Previous filing: Aug 4, 2025
SEC: View on sec.gov

Reporting Owners (5)

Name	Relationship	Address	Signature	Signature date	CIK
ABG Management Ltd.	10%+ Owner	#3902, 39/F, E TOWER,, 10 HARCOURT RD CTR, HONG KONG, HONG KONG	ABG Management Ltd., By: /s/ Fan Yu, Director	2025-10-24	0001832106
Ally Bridge MedAlpha Master Fund L.P.	10%+ Owner	C/O MAPLES CORPORATE SERVICES LIMITED,, P.O. BOX 309, UGLAND HOUSE,, GRAND CAYMAN, CAYMAN ISLANDS	Ally Bridge MedAlpha Master Fund L.P., By: Ally Bridge Group (NY) LLC, its manager, By: ABG Management Ltd., its managing member, By: /s/ Fan Yu, Director	2025-10-24	0001831963
Ally Bridge Group (NY) LLC	10%+ Owner	430 PARK AVENUE, 12TH FLOOR, NEW YORK,	Ally Bridge Group (NY) LLC, By: ABG Management Ltd., its managing member, By: /s/ Fan Yu, Director	2025-10-24	0001822947
Yu Fan	10%+ Owner	#3902, 39/F, E TOWER,, 10 HARCOURT RD CTR, HONG KONG, HONG KONG	/s/ Fan Yu	2025-10-24	0001668029
Alex Slanix Paul	Director	C/O PROMIS NEUROSCIENCES INC., SUITE 200, 1920 YONGE STREET, TORONTO,, ONTARIO, CANADA	/s/ Max A. Milbury, Attorney-in-Fact for Slanix Paul Alex	2025-10-24	0002092283

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PMN	Option (right to buy)	Award	$0	+40K		$0.00	40K	Oct 22, 2025	Common Shares	40K	$0.45	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	25% of the shares subject to this option vested on the date of grant and the remaining shares shall vest in thirty-six equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.
F2	This option was granted to Slanix Alex, a director of the Issuer and an employee of Ally Bridge Group (NY) LLC, which manages the investments of Ally Bridge MedAlpha Master Fund L.P. Dr. Alex holds any equity-based compensation awarded to him for his service as a director of the Issuer for the benefit of Ally Bridge MedAlpha Master Fund L.P. Any proceeds from the sale of shares upon exercise of this award shall be remitted to Ally Bridge MedAlpha Master Fund L.P. The Reporting Person disclaims beneficial ownership of such securities for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such securities are beneficially owned by him for Section 16 or any other purpose.

Content

25% of the shares subject to this option vested on the date of grant and the remaining shares shall vest in thirty-six equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

This option was granted to Slanix Alex, a director of the Issuer and an employee of Ally Bridge Group (NY) LLC, which manages the investments of Ally Bridge MedAlpha Master Fund L.P. Dr. Alex holds any equity-based compensation awarded to him for his service as a director of the Issuer for the benefit of Ally Bridge MedAlpha Master Fund L.P. Any proceeds from the sale of shares upon exercise of this award shall be remitted to Ally Bridge MedAlpha Master Fund L.P. The Reporting Person disclaims beneficial ownership of such securities for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such securities are beneficially owned by him for Section 16 or any other purpose.