Samir Gharib - Oct 20, 2025 Form 4 Insider Report for SPRUCE BIOSCIENCES, INC. (SPRB)

Role
PRESIDENT AND CFO
Signature
/s/ Samir Gharib
Stock symbol
SPRB
Transactions as of
Oct 20, 2025
Transactions value $
-$97,934
Form type
4
Date filed
10/22/2025, 04:15 PM
Previous filing
Dec 20, 2024
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Gharib Samir M. PRESIDENT AND CFO C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO /s/ Samir Gharib 2025-10-22 0001533302

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction SPRB Common Stock Options Exercise $0 +2.05K +43.92% $0.00 6.73K Oct 20, 2025 Direct F1, F2
transaction SPRB Common Stock Tax liability -$97.9K -661 -9.83% $148.16 6.07K Oct 20, 2025 Direct F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction SPRB Restricted Stock Units Award $0 +2.05K $0.00 2.05K Oct 20, 2025 Common Stock 2.05K $0.00 Direct F1, F2
transaction SPRB Restricted Stock Units Options Exercise $0 -2.05K -100% $0.00 0 Oct 20, 2025 Common Stock 2.05K $0.00 Direct F1, F2
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 On March 14, 2024, the Reporting Person was granted 2,053 performance-based RSUs. On October 20, 2025, the Issuer's Board of Directors certified that certain specified performance goals were met and all of the RSUs vested. 661 shares were withheld for taxes, resulting in a net issuance of 1,392 shares.
F2 Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of SPRB common stock.