- 
        Signature
      
 
      - 
        /s/ John B. Moriarty, Jr., J.D., Attorney-in-Fact
      
 
    
    
      
- 
        Stock symbol
      
 
      - 
        RNA
      
 
    
    
      
- 
        Transactions as of
      
 
      - 
        Oct 15, 2025
      
 
    
    
      
- 
        Transactions value $
      
 
      - 
        -$556,258
      
 
    
    
      
- 
        Form type
      
 
      - 
        4
      
 
    
    
      
- 
        Date filed
      
 
      - 
        10/17/2025, 04:27 PM
      
 
    
    
    
   
     
   
 
  
    Reporting Owners (1)
  
  
    
      
        
          | Name | 
          Relationship | 
          Address | 
          Signature | 
          Signature date | 
          CIK | 
        
      
      
          
            | McCarthy Teresa | 
            Chief Human Resources Officer | 
            C/O AVIDITY BIOSCIENCES, INC., 3020 CALLAN RD., SAN DIEGO | 
            /s/ John B. Moriarty, Jr., J.D., Attorney-in-Fact | 
            2025-10-17 | 
            0001862121 | 
          
      
    
   
  
    Transactions Table
  
  
    
      
        
          | Type | 
          Sym | 
          Class | 
          Transaction | 
          Value $ | 
          Shares | 
          Change % | 
          * Price $ | 
          Shares After | 
          Date | 
          Ownership | 
          Footnotes | 
        
      
      
          
            | transaction | 
            RNA | 
            Common Stock | 
            Options Exercise | 
            $447K | 
            +20K | 
            +20.59% | 
            $22.34 | 
            117K | 
            Oct 15, 2025 | 
            Direct | 
            F1 | 
          
          
            | transaction | 
            RNA | 
            Common Stock | 
            Sale | 
            -$1M | 
            -20K | 
            -17.08% | 
            $50.15 | 
            97.1K | 
            Oct 15, 2025 | 
            Direct | 
            F1, F2 | 
          
      
    
   
  
    Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)
  
  
    
      
        
          | Type | 
          Sym | 
          Class | 
          Transaction | 
          Value $ | 
          Shares | 
          Change % | 
          * Price $ | 
          Shares After | 
          Date | 
          Underlying Class | 
          Amount | 
          Exercise Price | 
          Ownership | 
          Footnotes | 
        
      
      
          
            | transaction | 
            RNA | 
            Stock Option (Right to Buy) | 
            Options Exercise | 
            $0 | 
            -20K | 
            -23.53% | 
            $0.00 | 
            65K | 
            Oct 15, 2025 | 
            Common Stock | 
            20K | 
            $22.34 | 
            Direct | 
            F1, F3 | 
          
      
    
   
  
    * An asterisk sign (*) next to the price indicates that the price is likely invalid.
  
  Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
  Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
  
    Explanation of Responses: