| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| BATE KENNETH | Director | C/O MADRIGAL PHARMACEUTICALS, INC., 200 BARR HARBOR DRIVE, SUITE 400, WEST CONSHOHOCKEN | /s/ Mardi Dier, as Attorney-in-Fact | 2025-11-07 | 0001210238 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | MDGL | Common Stock | Options Exercise | $51.7K | +5.47K | +208.22% | $9.45 | 8.1K | Nov 5, 2025 | Direct | |
| transaction | MDGL | Common Stock | Options Exercise | $3.04M | +10K | +123.5% | $303.79 | 18.1K | Nov 5, 2025 | Direct | |
| transaction | MDGL | Common Stock | Options Exercise | $309K | +1.11K | +6.11% | $280.04 | 19.2K | Nov 5, 2025 | Direct | |
| transaction | MDGL | Common Stock | Sale | -$847K | -1.76K | -9.18% | $480.24 | 17.4K | Nov 5, 2025 | Direct | F1 |
| transaction | MDGL | Common Stock | Sale | -$1.57M | -3.26K | -18.69% | $481.13 | 14.2K | Nov 5, 2025 | Direct | F2 |
| transaction | MDGL | Common Stock | Sale | -$619K | -1.28K | -9.06% | $482.41 | 12.9K | Nov 5, 2025 | Direct | F3 |
| transaction | MDGL | Common Stock | Sale | -$1M | -2.07K | -16.04% | $483.41 | 10.8K | Nov 5, 2025 | Direct | F4 |
| transaction | MDGL | Common Stock | Sale | -$936K | -1.93K | -17.84% | $484.78 | 8.9K | Nov 5, 2025 | Direct | F5 |
| transaction | MDGL | Common Stock | Sale | -$489K | -1.01K | -11.33% | $485.54 | 7.89K | Nov 5, 2025 | Direct | F6 |
| transaction | MDGL | Common Stock | Sale | -$403K | -827 | -10.48% | $486.73 | 7.06K | Nov 5, 2025 | Direct | F7 |
| transaction | MDGL | Common Stock | Sale | -$1.35M | -2.78K | -39.3% | $487.49 | 4.29K | Nov 5, 2025 | Direct | F8 |
| transaction | MDGL | Common Stock | Sale | -$340K | -696 | -16.24% | $489.09 | 3.59K | Nov 5, 2025 | Direct | F9 |
| transaction | MDGL | Common Stock | Sale | -$457K | -933 | -25.99% | $489.95 | 2.66K | Nov 5, 2025 | Direct | F10 |
| transaction | MDGL | Common Stock | Sale | -$14.7K | -30 | -1.13% | $490.98 | 2.63K | Nov 5, 2025 | Direct | F11 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | MDGL | Stock Option (Right to Buy) | Options Exercise | $0 | -5.47K | -100% | $0.00 | 0 | Nov 5, 2025 | Common Stock | 5.47K | $9.45 | Direct | F12 |
| transaction | MDGL | Stock Option (Right to Buy) | Options Exercise | $0 | -10K | -100% | $0.00 | 0 | Nov 5, 2025 | Common Stock | 10K | $303.79 | Direct | F12 |
| transaction | MDGL | Stock Option (Right to Buy) | Options Exercise | $0 | -1.11K | -100% | $0.00 | 0 | Nov 5, 2025 | Common Stock | 1.11K | $280.04 | Direct | F12 |
| Id | Content |
|---|---|
| F1 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $479.66 to $480.64, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. |
| F2 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $480.71 to $481.68, inclusive. |
| F3 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $481.84 to $482.71, inclusive. |
| F4 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $483.00 to $483.92, inclusive. |
| F5 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $484.02 to $485.015, inclusive. |
| F6 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $485.10 to $486.04, inclusive. |
| F7 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $486.10 to $486.99, inclusive. |
| F8 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $487.13 to $488.09, inclusive. |
| F9 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $488.74 to $489.49, inclusive. |
| F10 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $489.74 to $490.7125, inclusive. |
| F11 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $490.7625 to $491.42, inclusive. |
| F12 | The shares underlying this option are fully vested and exercisable. |