Robert Ragusa - 03 Dec 2025 Form 4 Insider Report for GRAIL, Inc. (GRAL)

Role: Chief Executive Officer, Director
Signature: /s/Abram Barth, as Attorney-in-Fact for Robert Ragusa
Issuer symbol: GRAL
Transactions as of: 03 Dec 2025
Transactions value $: -$3,809,535
Form type: 4
Date filed: 05 Dec 2025, 16:12
Previous filing: 16 Oct 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
RAGUSA ROBERT P	Chief Executive Officer, Director	C/O GRAIL, INC., 1525 O'BRIEN DRIVE, MENLO PARK	/s/Abram Barth, as Attorney-in-Fact for Robert Ragusa	2025-12-05	0001222644

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GRAL	Common Stock	Sale	-$1.4M	-14.8K	-2.03%	$94.43	713K	03 Dec 2025	Direct	F1, F2
transaction	GRAL	Common Stock	Sale	-$1.46M	-15.4K	-2.15%	$95.28	698K	03 Dec 2025	Direct	F3
transaction	GRAL	Common Stock	Sale	-$792K	-8.23K	-1.18%	$96.22	690K	03 Dec 2025	Direct	F4
transaction	GRAL	Common Stock	Sale	-$156K	-1.6K	-0.23%	$97.28	688K	03 Dec 2025	Direct	F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.78 to $94.7750 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.
F2	Includes 641 shares acquired under the Company's ESPP purchased on November 14, 2025.
F3	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.79 to $95.7850 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.
F4	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.88 to $96.82 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.
F5	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.89 to $97.79 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate sales price within the range set forth in this footnote.