| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Huang Jane | President, CMO | C/O PRELUDE THERAPEUTICS INCORPORATED, 175 INNOVATION BOULEVARD, WILMINGTON | /s/ Bryant D. Lim, Attorney-in-Fact | 2025-10-07 | 0001683913 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PRLD | Common Stock | Options Exercise | +9.38K | +11.59% | 90.3K | Oct 4, 2025 | Direct | F1 | ||
| transaction | PRLD | Common Stock | Tax liability | -$4.93K | -3.36K | -3.72% | $1.47 | 86.9K | Oct 4, 2025 | Direct | F2 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PRLD | Restricted Stock Unit | Options Exercise | $0 | -9.38K | -33.33% | $0.00 | 18.8K | Oct 4, 2025 | Common Stock | 9.38K | Direct | F1, F3 |
| Id | Content |
|---|---|
| F1 | Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Issuer's Common Stock. |
| F2 | Represents shares withheld by the Issuer to satisfy the tax withholding obligation in connection with the vesting of RSUs. |
| F3 | The RSUs were granted on May 2, 2022 and vest according to the reporting person's employment agreement. The RSUs vested as to 1/4 of the total shares on April 4, 2023, and 1/16 of the remaining shares shall vest quarterly thereafter until fully vested, subject to the continued service of the Reporting Person to the Issuer through each vesting date. |