| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Options Exercise | $241,250 | +33,979 | +15.82% | $7.1* | 248,744 | 13 May 2021 | Direct | F1 |
| transaction | ALNY | Common Stock | Sale | -$386,824 | -3,015 | -1.21% | $128.3 | 245,729 | 13 May 2021 | Direct | F1, F2 |
| transaction | ALNY | Common Stock | Sale | -$583,491 | -4,512 | -1.84% | $129.32 | 241,217 | 13 May 2021 | Direct | F1, F3 |
| transaction | ALNY | Common Stock | Sale | -$1,188,831 | -9,121 | -3.78% | $130.34 | 232,096 | 13 May 2021 | Direct | F1, F4 |
| transaction | ALNY | Common Stock | Sale | -$1,469,609 | -11,203 | -4.83% | $131.18 | 220,893 | 13 May 2021 | Direct | F1, F5 |
| transaction | ALNY | Common Stock | Sale | -$460,605 | -3,481 | -1.58% | $132.32 | 217,412 | 13 May 2021 | Direct | F1, F6 |
| transaction | ALNY | Common Stock | Sale | -$216,901 | -1,624 | -0.75% | $133.56 | 215,788 | 13 May 2021 | Direct | F1, F7 |
| transaction | ALNY | Common Stock | Sale | -$137,460 | -1,023 | -0.47% | $134.37 | 214,765 | 13 May 2021 | Direct | F1, F8 |
| holding | ALNY | Common Stock | 3,133 | 13 May 2021 | by Managed Account | F9 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Stock Option (right to buy) | Options Exercise | $0 | -33,979 | -33.33% | $0 | 67,957 | 13 May 2021 | Common Stock | 33,979 | $7.1 | Direct | F1, F10 |
| Id | Content |
|---|---|
| F1 | All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021. |
| F2 | Sale prices ranged from $127.73 to $128.73. |
| F3 | Sale prices ranged from $128.80 to $129.77. |
| F4 | Sale prices ranged from $129.81 to $130.81. |
| F5 | Sale prices ranged from $130.82 to $131.81. |
| F6 | Sale prices ranged from $131.84 to $132.78. |
| F7 | Sale prices ranged from $132.97 to $133.77. |
| F8 | Sale prices ranged from $134.11 to $134.40. |
| F9 | Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program. |
| F10 | The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter. |