JOHN MARAGANORE - 12 Nov 2021 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Role: Chief Executive Officer, Director
Signature: By: /s/ Mary Beth DeLena, Attorney-in-Fact For: John M. Maraganore
Issuer symbol: ALNY
Transactions as of: 12 Nov 2021
Transactions value $: -$5,586,557
Form type: 4
Filing time: 12 Nov 2021, 16:52:13 UTC
Previous filing: 08 Nov 2021
Next filing: 14 Dec 2021
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ALNY	Common Stock	Options Exercise	$241,243	+33,978	+15.82%	$7.1^*	248,743	12 Nov 2021	Direct	F1
transaction	ALNY	Common Stock	Sale	-$1,765,781	-10,365	-4.17%	$170.36	238,378	12 Nov 2021	Direct	F1, F2
transaction	ALNY	Common Stock	Sale	-$1,326,591	-7,742	-3.25%	$171.35	230,636	12 Nov 2021	Direct	F1, F3
transaction	ALNY	Common Stock	Sale	-$2,500,289	-14,518	-6.29%	$172.22	216,118	12 Nov 2021	Direct	F1, F4
transaction	ALNY	Common Stock	Sale	-$118,329	-683	-0.32%	$173.25	215,435	12 Nov 2021	Direct	F1, F5
transaction	ALNY	Common Stock	Sale	-$116,807	-670	-0.31%	$174.34	214,765	12 Nov 2021	Direct	F1, F6
holding	ALNY	Common Stock						3,133	12 Nov 2021	by Managed Account	F7

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	ALNY	Stock Option (right to buy)	Options Exercise	$0	-33,978	-100%	$0^*	0	12 Nov 2021	Common Stock	33,978	$7.1	Direct	F1, F8

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,978 options exercised and sold by the reporting person were due to expire on November 30, 2021.
F2	Sale prices ranged from $169.84 to $170.84.
F3	Sale prices ranged from $170.85 to $171.82.
F4	Sale prices ranged from $171.86 to $172.84.
F5	Sale prices ranged from $172.90 to $173.34.
F6	Sale prices ranged from $174.05 to $174.63.
F7	Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.
F8	The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.