| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Award | $0 | +15.1K | +44.6% | $0.00 | 49K | Mar 3, 2025 | Direct | F1, F2 |
| transaction | ALNY | Common Stock | Sale | -$84.8K | -350 | -0.71% | $242.37 | 48.7K | Mar 3, 2025 | Direct | F3, F4 |
| transaction | ALNY | Common Stock | Sale | -$93K | -382 | -0.78% | $243.36 | 48.3K | Mar 3, 2025 | Direct | F3, F5 |
| transaction | ALNY | Common Stock | Sale | -$63.1K | -258 | -0.53% | $244.41 | 48K | Mar 3, 2025 | Direct | F3, F6 |
| transaction | ALNY | Common Stock | Sale | -$46.4K | -189 | -0.39% | $245.26 | 47.8K | Mar 3, 2025 | Direct | F3, F7 |
| transaction | ALNY | Common Stock | Sale | -$19K | -77 | -0.16% | $246.18 | 47.8K | Mar 3, 2025 | Direct | F3, F8 |
| transaction | ALNY | Common Stock | Sale | -$1.73K | -7 | -0.01% | $247.35 | 47.8K | Mar 3, 2025 | Direct | F3, F9 |
| transaction | ALNY | Common Stock | Sale | -$248 | -1 | 0% | $248.36 | 47.8K | Mar 3, 2025 | Direct | F3 |
| holding | ALNY | Common Stock | 57 | Mar 3, 2025 | by Managed Account | F10 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Stock Option (right to buy) | Award | $0 | +9.8K | $0.00 | 9.8K | Mar 3, 2025 | Common Stock | 9.8K | $243.53 | Direct | F11 |
| Id | Content |
|---|---|
| F1 | These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest over a three-year period, with one third vesting on each of the first, second and third anniversaries of the grant date, subject to the Reporting Persons continuous service with the Issuer as of each such vesting date. |
| F2 | The Reporting Person has reported certain prior awards of RSUs in Table II of Form 4. The total reported in Column 5 includes the 15,117, newly awarded RSUs and 32,634 shares of common stock. The Reporting Person also holds 1,908 unvested RSUs that were previously reported in Table II. |
| F3 | Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units. |
| F4 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $241.87 to $242.86. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F5 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $242.89 to $243.88. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F6 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $243.90 to $244.90. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F7 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $244.91 to $245.88. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F8 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $246.00 to $246.71. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F9 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $247.04 to $247.52. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F10 | Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program. |
| F11 | The stock option vests as to 25% of the shares on the first anniversary of the grant date and the remaining shares vest in equal installments at the end of each successive three-month period thereafter until the fourth anniversary of the grant date, subject to the Reporting Persons continuous service with the Issuer as of each such vesting date. |