Dennis A. Ausiello - Aug 14, 2025 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Role
Director
Signature
By: Brett Budzinski, Attorney-in-Fact For: Dennis A. Ausiello
Stock symbol
ALNY
Transactions as of
Aug 14, 2025
Transactions value $
-$9,599,057
Form type
4
Date filed
8/15/2025, 04:05 PM
Previous filing
Jul 2, 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Ausiello Dennis A Director 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE By: Brett Budzinski, Attorney-in-Fact For: Dennis A. Ausiello 2025-08-15 0001381994

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction ALNY Common Stock Options Exercise $648K +9K +987.93% $72.01 9.91K Aug 14, 2025 Direct F1
transaction ALNY Common Stock Options Exercise $661K +5.15K +51.99% $128.31 15.1K Aug 14, 2025 Direct F1
transaction ALNY Common Stock Options Exercise $682K +4.58K +30.41% $148.77 19.6K Aug 14, 2025 Direct F1
transaction ALNY Common Stock Options Exercise $791K +5.23K +26.61% $151.22 24.9K Aug 14, 2025 Direct F1
transaction ALNY Common Stock Options Exercise $693K +4.03K +16.21% $171.95 28.9K Aug 14, 2025 Direct F1
transaction ALNY Common Stock Options Exercise $656K +3.45K +11.95% $189.87 32.4K Aug 14, 2025 Direct F1
transaction ALNY Common Stock Sale -$855K -1.99K -6.13% $430.81 30.4K Aug 14, 2025 Direct F1, F2
transaction ALNY Common Stock Sale -$839K -1.94K -6.38% $432.94 28.4K Aug 14, 2025 Direct F1, F3
transaction ALNY Common Stock Sale -$912K -2.1K -7.38% $434.50 26.3K Aug 14, 2025 Direct F1, F4
transaction ALNY Common Stock Sale -$3.34M -7.68K -29.14% $435.40 18.7K Aug 14, 2025 Direct F1, F5
transaction ALNY Common Stock Sale -$2.34M -5.36K -28.71% $436.00 13.3K Aug 14, 2025 Direct F1, F6
transaction ALNY Common Stock Sale -$841K -1.92K -14.45% $437.56 11.4K Aug 14, 2025 Direct F1, F7
transaction ALNY Common Stock Sale -$914K -2.09K -18.33% $438.34 9.3K Aug 14, 2025 Direct F1, F8
transaction ALNY Common Stock Sale -$2.33M -5.3K -57.03% $439.27 4K Aug 14, 2025 Direct F1, F9
transaction ALNY Common Stock Sale -$545K -1.24K -30.99% $440.54 2.76K Aug 14, 2025 Direct F1, F10
transaction ALNY Common Stock Sale -$532K -1.21K -43.71% $441.88 1.55K Aug 14, 2025 Direct F1, F11
transaction ALNY Common Stock Sale -$284K -641 -41.3% $442.66 911 Aug 14, 2025 Direct F1, F12
holding ALNY Common Stock 3.5K Aug 14, 2025 by Trust F13

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction ALNY Stock Option (right to buy) Options Exercise $0 -9K -100% $0.00 0 Aug 14, 2025 Common Stock 9K $72.01 Direct F1, F14
transaction ALNY Stock Option (right to buy) Options Exercise $0 -5.15K -100% $0.00 0 Aug 14, 2025 Common Stock 5.15K $128.31 Direct F1, F15
transaction ALNY Stock Option (right to buy) Options Exercise $0 -4.58K -100% $0.00 0 Aug 14, 2025 Common Stock 4.58K $148.77 Direct F1, F16
transaction ALNY Stock Option (right to buy) Options Exercise $0 -5.23K -100% $0.00 0 Aug 14, 2025 Common Stock 5.23K $151.22 Direct F1, F17
transaction ALNY Stock Option (right to buy) Options Exercise $0 -4.03K -100% $0.00 0 Aug 14, 2025 Common Stock 4.03K $171.95 Direct F1, F18
transaction ALNY Stock Option (right to buy) Options Exercise $0 -3.45K -100% $0.00 0 Aug 14, 2025 Common Stock 3.45K $189.87 Direct F1, F19
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 All transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on May 15, 2025.
F2 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $430.39 to $431.24. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F3 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $432.10 to $433.06. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F4 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $433.59 to $434.56. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F5 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $434.69 to $435.66. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F6 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $435.79 to $436.35 The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F7 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $436.84 to $437.83 The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F8 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $437.85 to $438.71 The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F9 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $438.91 to $439.89 The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F10 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $440.24 to $440.93 The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F11 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $441.41 to $442.11 The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F12 The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $442.44 to $443.10 The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F13 The shares of ALNY common stock are held in a trust, of which the reporting person's spouse is the trustee.
F14 The stock option was fully vested as of July 1, 2020.
F15 The stock option was fully vested as of May 18, 2023.
F16 The stock option was fully vested as of July 1, 2021.
F17 The stock option was fully vested as of May 16, 2025.
F18 The stock option was fully vested as of July 15, 2022.
F19 The stock option was fully vested as of May 18, 2024.