Allan Reine - 19 May 2025 Form 4 Insider Report for Prime Medicine, Inc. (PRME)

Role: Chief Executive Officer, Director
Signature: /s/ Ryan Brown, attorney-in-fact
Issuer symbol: PRME
Transactions as of: 19 May 2025
Transactions value $: $0
Form type: 4
Filing time: 19 May 2025, 19:44:15 UTC
Previous filing: 12 May 2025
Next filing: 22 May 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Reine Allan	Chief Executive Officer, Director	C/O PRIME MEDICINE, INC., 60 FIRST STREET, CAMBRIDGE	/s/ Ryan Brown, attorney-in-fact	19 May 2025	0001714023

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PRME	Stock Option (right to buy)	Award	$0	+2M		$0.00	2M	19 May 2025	Common Stock	2M	$1.34	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	25% of the shares underlying this option shall vest and become exercisable on May 19, 2026, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.