Stephen Paul O'Brien - 16 Dec 2025 Form 4 Insider Report for Tvardi Therapeutics, Inc. (TVRD)

Role: Principal Accounting Officer
Signature: /s/ Dan Conn, Attorney-in-Fact
Issuer symbol: TVRD
Transactions as of: 16 Dec 2025
Transactions value $: $0
Form type: 4
Filing time: 18 Dec 2025, 17:00:14 UTC
Previous filing: 21 Apr 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
O'Brien Stephen Paul	Principal Accounting Officer	C/O TVARDI THERAPEUTICS, INC., 3 SUGAR CREEK CTR BLVD, STE 525, SUGAR LAND	/s/ Dan Conn, Attorney-in-Fact	18 Dec 2025	0002064889

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	TVRD	Employee Stock Option (right to buy)	Award	$0	+4,000		$0.000000	4,000	16 Dec 2025	Common Stock	4,000	$4.20	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	25% of the shares subject to the option shall vest on December 16, 2026, and the balance of the shares subject to the option shall vest in equal monthly installments over the following 36 months, subject to the Reporting Person's continuous service through each applicable vesting date.