| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| BB Biotech AG | 6.2% | 3.52M | 0 | 3.52M | /s/ Martin Gubler | Martin Gubler/Signatory Authority | |
| Biotech Target N.V. | 6.2% | 3.52M | 0 | 3.52M | /s/ Jan Bootsma | Jan Bootsma/Signatory Authority |