| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| BB Biotech AG | 15% | 8,517,839 | 0 | 8,517,839 | /s/ Martin Gubler | Martin Gubler/Signatory Authority | |
| Biotech Growth N.V. | 15% | 8,517,839 | 0 | 8,517,839 | /s/ Jan Bootsma | Jan Bootsma/Signatory Authority |