| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| PFM Health Sciences, LP | 6.4% | 3.3M | 0 | 3.3M | /s/ Darren Mooney | Darren Mooney, Authorized Signatory | |
| PFM Health Sciences GP, LLC | 6.4% | 3.3M | 0 | 3.3M | /s/ Darren Mooney | Darren Mooney, Authorized Signatory | |
| Partner Asset Management, LLC | 6.4% | 3.3M | 0 | 3.3M | /s/ Darren Mooney | Darren Mooney, Authorized Signatory | |
| Brian D. Grossman | 6.4% | 3.3M | 0 | 3.3M | /s/ Darren Mooney | Darren Mooney, attorney-in-fact* |