| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Paradigm BioCapital Advisors LP | 5.3% | 15,159,095 | 15,159,095 | 0 | /s/ David K. Kim | David K. Kim / Authorized Signatory | |
| Paradigm BioCapital Advisors GP LLC | 5.3% | 15,159,095 | 15,159,095 | 0 | /s/ David K. Kim | David K. Kim / Authorized Signatory | |
| Senai Asefaw, M.D. | 5.3% | 15,159,095 | 15,159,095 | 0 | /s/ Senai Asefaw, M.D. | N/A | |
| Paradigm BioCapital International Fund Ltd. | 4.7% | 13,377,027 | 13,377,027 | 0 | /s/ David K. Kim | David K. Kim / Authorized Signatory |