| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10% | 14,885,421 | 0 | 14,885,421 | Kristin Mariani | Head of North America Compliance, CCO | |
| Janus Henderson Biotech Innovation Master Fund Ltd | 6% | 8,897,507 | 0 | 8,897,507 | Kristin Mariani | Head of North America Compliance, CCO |