| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RTW Investments, LP | 15% | 8,306,063 | 0 | 8,306,063 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Managing Partner | 0001493215 |
| RTW Master Fund, Ltd. | 8.1% | 4,394,985 | 0 | 4,394,985 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Director | 0001493219 |
| RTW Innovation Master Fund, Ltd. | 5.7% | 3,053,082 | 0 | 3,053,082 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Director | 0001776733 |
| Roderick Wong | 15% | 8,306,063 | 0 | 8,306,063 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D. | 0001493280 |