| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RTW Investments, LP | 4.2% | 7,144,524 | 0 | 7,144,524 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Managing Partner | |
| Roderick Wong | 4.2% | 7,144,524 | 0 | 7,144,524 | s/ Roderick Wong, M.D. | Roderick Wong, M.D. |