Upstream Bio, Inc. financial data

Symbol
UPB on Nasdaq
Location
890 Winter Street, Suite 200, Waltham, MA
Fiscal year end
December 31
Latest financial report
10-Q - Q3 2025 - Nov 5, 2025

Key Ratios

Label TTM Value / Value Unit Change %
Current Ratio 4.03K %
Debt-to-equity 2.75 %
Return On Equity -28.7 % -176%
Return On Assets -27.9 %
Operating Margin -5.02K %

Shares

Label TTM Value / Value Unit Change %
Entity Common Stock, Shares Outstanding 54M shares +0.83%
Common Stock, Shares, Outstanding 54M shares +1685%
Common Stock, Value, Issued 56K USD +1767%
Weighted Average Number of Shares Outstanding, Basic 53.9M shares +1684%
Weighted Average Number of Shares Outstanding, Diluted 53.9M shares +1684%

Income Statement

Label TTM Value / Value Unit Change %
Revenue from Contract with Customer, Excluding Assessed Tax 2.8M USD +12.5%
Research and Development Expense 118M USD +114%
General and Administrative Expense 24.9M USD +36.3%
Operating Income (Loss) -141M USD -100%
Nonoperating Income (Expense) 18.3M USD +40.8%
Income Tax Expense (Benefit) 0 USD
Net Income (Loss) Attributable to Parent -122M USD -129%
Earnings Per Share, Basic 10 USD/shares +90.9%
Earnings Per Share, Diluted 10 USD/shares +90.9%

Balance Sheet

Label TTM Value / Value Unit Change %
Cash and Cash Equivalents, at Carrying Value 72.2M USD +119%
Accounts Receivable, after Allowance for Credit Loss, Current 683K USD +12.5%
Assets, Current 389M USD +71.2%
Property, Plant and Equipment, Net 616K USD +6.57%
Operating Lease, Right-of-Use Asset 1.37M USD -28.5%
Goodwill 0 USD
Assets 391M USD +68.1%
Accounts Payable, Current 3.95M USD -19.3%
Employee-related Liabilities, Current 3.04M USD +51.9%
Liabilities, Current 11.9M USD +9.51%
Operating Lease, Liability, Noncurrent 703K USD -44.3%
Liabilities 12.6M USD +3.91%
Accumulated Other Comprehensive Income (Loss), Net of Tax 493K USD +40.5%
Retained Earnings (Accumulated Deficit) -292M USD -72.1%
Stockholders' Equity Attributable to Parent 379M USD
Liabilities and Equity 391M USD +68.1%

Popular Metrics

Label TTM Value / Value Unit Change %
Net Cash Provided by (Used in) Operating Activities -41.2M USD -134%
Net Cash Provided by (Used in) Financing Activities -34K USD -100%
Net Cash Provided by (Used in) Investing Activities -213M USD -1640%
Common Stock, Shares Authorized 500M shares +1129%
Common Stock, Shares, Issued 54M shares +1685%
Common Stock, Par or Stated Value Per Share 0 USD/shares 0%
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect -255M USD -4584%
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents 72.4M USD +118%
Deferred Tax Assets, Valuation Allowance 60.7M USD +52.8%
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 0 pure
Deferred Tax Assets, Gross 61.2M USD +54%
Operating Lease, Liability 1.83M USD
Comprehensive Income (Loss), Net of Tax, Attributable to Parent -122M USD -115%
Lessee, Operating Lease, Liability, to be Paid 2.15M USD
Property, Plant and Equipment, Gross 903K USD +31.8%
Operating Lease, Liability, Current 716K USD +5.61%
Lessee, Operating Lease, Liability, to be Paid, Year Two 800K USD 0%
Lessee, Operating Lease, Liability, to be Paid, Year One 700K USD 0%
Operating Lease, Weighted Average Discount Rate, Percent 0.12 pure -25.5%
Lessee, Operating Lease, Liability, Undiscounted Excess Amount 311K USD
Lessee, Operating Lease, Liability, to be Paid, Year Three 800K USD 0%
Deferred Tax Assets, Operating Loss Carryforwards 11M USD +57.4%
Preferred Stock, Shares Issued 0 shares
Preferred Stock, Shares Authorized 10M shares
Unrecognized Tax Benefits 0 USD
Additional Paid in Capital 670M USD +7449%
Preferred Stock, Shares Outstanding 0 shares
Depreciation, Depletion and Amortization 43K USD +231%
Deferred Tax Assets, Net of Valuation Allowance 488K USD +3967%
Share-based Payment Arrangement, Expense 9.91M USD +39.2%
Preferred Stock, Par or Stated Value Per Share 0 USD/shares