Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Historical Holders from Q4 2024 to Q3 2025

Symbol
UPB on Nasdaq
CUSIP
91678A107
Type / Class
Equity / Common Stock, par value $0.001 per share
Shares outstanding
54.3M
All holders as of September 30, 2025
Q3 2025
Total 13F shares, excl. options
44.5M
Holdings value
$836M
% of all portfolios
0.003%
Grand Portfolio weight change
0%
Number of holders
94
Number of buys
59
Number of sells
-32
Average Value change %
0%
Average buys %
+0%
Average sells %
-0.001%
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
FMR LLC 14.8% +10.8% $75.4M $7.23M 7.94M +10.6% FMR LLC Jun 30, 2025
Decheng Capital Global Life Sciences Fund IV, L.P. 6.1% $24.2M 3.29M Xiangmin Cui Dec 31, 2024
NORGES BANK 5.3% $54.2M 2.88M Norges Bank Sep 30, 2025
HBM Healthcare Investments (Cayman) Ltd. 4.1% -20% $41.3M -$9.78M 2.2M -19.2% HBM Healthcare Investments (Cayman) Ltd. Sep 30, 2025
TCG Crossover GP I, LLC 3.9% -26% $39.8M -$12.9M 2.12M -24.4% TCG Crossover GP I, LLC Sep 30, 2025

Institutional Holders of Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Period Reported Shares, Excl. Options Value, Excl. Options Change Price Investors
2025 Q3 44.5M $836M -$50.8M $18.81 94
2025 Q2 48.4M $531M +$32.7M $10.98 82
2025 Q1 42.1M $257M -$17.7M $6.12 76
2024 Q4 42.1M $690M +$650M $16.44 70