Opaleye Management Inc. - Insider Trading & Ownership

Location
One Boston Place, Suite 2600, Boston, MA
Summary
The estimated value of insider holdings of Opaleye Management Inc. is at least $230M dollars as of November 26, 2025. Opaleye Management Inc. is the 10%+ Owner of HARROW, INC. and owns shares of HARROW, INC. (HROW) stock worth about $104M. Opaleye Management Inc. is the 10%+ Owner of Eton Pharmaceuticals, Inc. and owns shares of Eton Pharmaceuticals, Inc. (ETON) stock worth about $45.2M. Opaleye Management Inc. is the 10%+ Owner of SANUWAVE Health, Inc. and owns shares of SANUWAVE Health, Inc. (SNWV) stock worth about $29.8M. Opaleye Management Inc. is the 10%+ Owner of CODEXIS, INC. and owns shares of CODEXIS, INC. (CDXS) stock worth about $20.9M. Opaleye Management Inc. is the 10%+ Owner of Sol-Gel Technologies Ltd. and owns shares of Sol-Gel Technologies Ltd. (SLGL) stock worth about $14.9M. Opaleye Management Inc. is the Former 10% Owner. of TELA Bio, Inc. and owns shares of TELA Bio, Inc. (TELA) stock worth about $11.7M. Opaleye Management Inc. is the 10%+ Owner of Protara Therapeutics, Inc. and owns shares of Protara Therapeutics, Inc. (TARA) stock worth about $3.4M.
Signature
Opaleye Management Inc., By: /s/ James Silverman, President
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Ownership of Opaleye Management Inc.

Symbol Company Relationship Holdings Value Past Year Net Change Change % Report Period
HROW, HROWL HARROW, INC. 10%+ Owner $104M -$2.91M -2.71% Jun 9, 2025
ETON Eton Pharmaceuticals, Inc. 10%+ Owner $45.2M +$125K +0.28% Jun 10, 2025
SNWV SANUWAVE Health, Inc. 10%+ Owner $29.8M +$242K +0.82% Oct 6, 2025
CDXS CODEXIS, INC. 10%+ Owner $20.9M +$10.4M +99.1% Nov 12, 2025
SLGL Sol-Gel Technologies Ltd. 10%+ Owner $14.9M +$245K +1.67% Nov 24, 2025
TELA TELA Bio, Inc. Former 10% Owner. $11.7M Apr 20, 2023
TARA Protara Therapeutics, Inc. 10%+ Owner $3.4M Sep 11, 2024
TCON Tracon Pharmaceuticals, Inc. 10%+ Owner Nov 10, 2023

Insider Transactions Reported by Opaleye Management Inc.:

Sym Company Class Transaction % Value $ * Price $ Shares Shares After Date Ownership
* An asterisk sign (*) next to the price indicates that the price is likely invalid.