| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 9.6% | $575,984,900 | 13,219,759 | The Vanguard Group | 30 Sep 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 7.1% | $426,459,326 | 9,787,912 | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 8.1% | $247,730,942 | 9,684,556 | Wellington Management Group LLP | 31 Mar 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 5.9% | $376,489,721 | 8,641,031 | RA Capital Management, L.P. | 30 Sep 2025 | |||
| BlackRock, Inc. | 6.4% | -14% | $376,086,262 | -$17,916,333 | 8,631,771 | -4.5% | BlackRock, Inc. | 30 Sep 2025 |
| JANUS HENDERSON GROUP PLC | 5.5% | -47% | $582,654,041 | -$446,149,257 | 8,224,930 | -43% | JANUS HENDERSON GROUP PLC | 28 Nov 2025 |
| RTW INVESTMENTS, LP | 3.1% | $204,173,813 | 4,686,110 | RTW Investments, LP | 27 Oct 2025 | |||
| FMR LLC | 2.1% | -86% | $128,911,093 | -$809,934,537 | 2,958,712 | -86% | FMR LLC | 31 Oct 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 14% | 21,585,984 | +33% | 0.05% | $940,501,305 |
| JANUS HENDERSON GROUP PLC | 9.7% | 14,522,915 | +35% | 0.29% | $632,808,722 |
| VANGUARD GROUP INC | 8.8% | 13,219,759 | +43% | 0.01% | $575,984,899 |
| RTW INVESTMENTS, LP | 7.6% | 11,372,829 | +18% | 6.1% | $495,514,160 |
| WELLINGTON MANAGEMENT GROUP LLP | 6.7% | 10,065,187 | +8.8% | 0.08% | $438,540,198 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6.5% | 9,787,417 | -9.4% | 0.05% | $426,438,000 |
| BlackRock, Inc. | 6.2% | 9,202,579 | -1.4% | 0.01% | $400,956,371 |
| RA CAPITAL MANAGEMENT, L.P. | 5.8% | 8,641,031 | +19% | 4.6% | $376,489,721 |
| Avoro Capital Advisors LLC | 5.1% | 7,645,000 | +8.4% | 4.3% | $333,092,650 |
| STATE STREET CORP | 3.3% | 4,888,632 | +16% | 0.01% | $212,997,696 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 2,858,049 | +0.35% | 0.01% | $124,547,400 |
| Polar Capital Holdings Plc | 1.9% | 2,796,760 | +58% | 0.59% | $121,854,833 |
| Bellevue Group AG | 1.4% | 2,152,862 | 1.9% | $93,800,197 | |
| Casdin Capital, LLC | 1.2% | 1,780,000 | +0.28% | 6.5% | $77,554,600 |
| GOLDMAN SACHS GROUP INC | 1.2% | 1,732,469 | +51% | 0.01% | $75,483,675 |
| BANK OF AMERICA CORP /DE/ | 1.2% | 1,725,186 | -6.2% | 0.01% | $75,166,353 |
| ORBIMED ADVISORS LLC | 1.1% | 1,638,886 | -9.6% | 1.7% | $71,406,263 |
| T. Rowe Price Investment Management, Inc. | 0.94% | 1,401,906 | +72% | 0.04% | $61,082,000 |
| Pictet Asset Management Holding SA | 0.89% | 1,338,091 | +38% | 0.06% | $58,234,125 |
| UBS Group AG | 0.88% | 1,315,859 | +121% | 0.01% | $57,331,977 |
| Siren, L.L.C. | 0.86% | 1,285,610 | +16% | 2.2% | $56,014,028 |
| Fiera Capital Corp | 0.8% | 1,202,384 | +54% | 0.17% | $52,387,871 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0.8% | 1,200,000 | -21% | 0.08% | $52,284,000 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.75% | 1,123,777 | +7.2% | 0.01% | $48,962,964 |
| NORTHERN TRUST CORP | 0.65% | 975,056 | -2.2% | 0.01% | $42,483,191 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 36,731 | $2,648,998 | -$2,255,117 | $72.13 | 7 |
| 2025 Q3 | 160,908,041 | $7,009,352,759 | +$1,158,003,556 | $43.57 | 268 |
| 2025 Q2 | 135,973,420 | $3,861,676,519 | +$69,697,386 | $28.40 | 205 |
| 2025 Q1 | 133,409,266 | $3,962,055,230 | +$178,441,325 | $29.52 | 218 |
| 2024 Q4 | 127,627,892 | $3,712,315,565 | -$47,544,719 | $29.08 | 232 |
| 2024 Q3 | 125,172,698 | $5,747,409,921 | +$525,069,616 | $45.93 | 239 |
| 2024 Q2 | 111,915,111 | $4,571,747,454 | +$938,345,183 | $40.85 | 191 |
| 2024 Q1 | 89,244,556 | $2,277,452,184 | +$379,403,859 | $25.52 | 155 |
| 2023 Q4 | 99,877 | $903,886 | -$575,553 | $9.05 | 2 |
| 2023 Q3 | 5,222,237 | $33,317,494 | -$4,349,883 | $6.38 | 14 |
| 2023 Q2 | 82,372,581 | $913,513,101 | +$45,839,333 | $11.09 | 138 |
| 2023 Q1 | 75,905,578 | $1,164,984,161 | +$45,103,010 | $15.35 | 136 |
| 2022 Q4 | 71,605,495 | $1,588,949,850 | +$414,642,652 | $22.19 | 145 |
| 2022 Q3 | 53,371,282 | $871,633,746 | -$46,945,339 | $16.33 | 116 |
| 2022 Q2 | 51,915,279 | $754,358,370 | +$37,157,871 | $14.53 | 100 |
| 2022 Q1 | 46,909,430 | $866,282,187 | +$27,212,352 | $18.47 | 93 |
| 2021 Q4 | 45,391,487 | $1,078,920,735 | +$3,605,438 | $23.77 | 101 |
| 2021 Q3 | 44,394,930 | $1,093,340,317 | +$239,536,085 | $24.63 | 109 |
| 2021 Q2 | 34,467,030 | $851,504,705 | +$17,357,609 | $24.71 | 92 |
| 2021 Q1 | 33,888,820 | $739,146,337 | +$60,776,521 | $21.81 | 97 |
| 2020 Q4 | 30,821,303 | $786,587,311 | +$74,431,621 | $25.52 | 81 |
| 2020 Q3 | 27,020,375 | $755,387,115 | +$43,761,743 | $28.15 | 66 |
| 2020 Q2 | 25,458,553 | $701,864,000 | +$701,298,980 | $28.26 | 52 |