| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RTW Investments, LP | 3.1% | 4,686,110 | 0 | 4,686,110 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Managing Partner | 0001493215 |
| Roderick Wong | 3.1% | 4,686,110 | 0 | 4,686,110 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D. | 0001493280 |