| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $8,106,040 | 2,122,000 | RA Capital Management, L.P. | 18 Jul 2025 | |||
| FRANKLIN RESOURCES INC | 7.7% | -13% | $19,453,682 | -$508,531 | 1,655,548 | -2.5% | Franklin Resources, Inc. | 30 Sep 2025 |
| SECTORAL ASSET MANAGEMENT INC | 5% | $6,142,078 | 950,786 | Jerome G. Pfund | 31 Dec 2024 | |||
| PERCEPTIVE ADVISORS LLC | 3.2% | -54% | $7,029,834 | -$7,454,718 | 699,486 | -51% | Perceptive Advisors LLC | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | 2,122,000 | 0.31% | $24,933,500 | |
| JOHNSON & JOHNSON | 9.2% | 1,979,173 | 0% | 4.6% | $23,255,283 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8% | 1,720,000 | 0% | 0.61% | $20,210,000 |
| FRANKLIN RESOURCES INC | 7.7% | 1,655,548 | -2.5% | 0% | $19,452,689 |
| VANGUARD GROUP INC | 4.5% | 964,232 | +30% | 0% | $11,329,726 |
| Balyasny Asset Management L.P. | 4.4% | 951,320 | 0.02% | $11,178,010 | |
| FMR LLC | 3.8% | 814,871 | -3.4% | 0% | $9,574,734 |
| SECTORAL ASSET MANAGEMENT INC | 3.7% | 800,787 | 0% | 5.8% | $9,409,247 |
| PERCEPTIVE ADVISORS LLC | 3.3% | 714,592 | +2.2% | 0.25% | $8,396,456 |
| HHLR ADVISORS, LTD. | 3.1% | 669,337 | 0% | 0.19% | $7,864,710 |
| MILLENNIUM MANAGEMENT LLC | 3% | 646,022 | +388% | 0.01% | $7,590,758 |
| RED TREE MANAGEMENT, LLC | 3% | 638,158 | 0% | 9% | $7,498,357 |
| SAMSARA BIOCAPITAL, LLC | 2.7% | 571,142 | -3% | 0.88% | $6,710,919 |
| Versant Venture Management, LLC | 2.5% | 542,628 | 0% | 3% | $6,375,879 |
| Point72 Asset Management, L.P. | 1.7% | 367,645 | -5.4% | 0.01% | $4,319,828 |
| BlackRock, Inc. | 1.5% | 322,031 | +95% | 0% | $3,783,865 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.98% | 211,050 | +196% | 0% | $2,481,056 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.95% | 204,119 | +914% | 0% | $2,398,398 |
| MARSHALL WACE, LLP | 0.9% | 193,491 | +575% | 0% | $2,273,522 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0.77% | 166,161 | 0.28% | $1,952,392 | |
| Casdin Capital, LLC | 0.69% | 148,333 | 0% | 0.15% | $1,742,913 |
| Eversept Partners, LP | 0.63% | 134,619 | 0.12% | $1,581,773 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.51% | 110,178 | +323% | 0% | $1,294,592 |
| MORGAN STANLEY | 0.43% | 92,995 | +0.1% | 0% | $1,092,692 |
| ADAR1 Capital Management, LLC | 0.36% | 77,961 | -53% | 0.09% | $916,042 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 0 | $0 | -$447 | 0 | |
| 2025 Q3 | 17,478,081 | $205,365,503 | +$48,626,440 | 1,175% | 61 |
| 2025 Q2 | 13,856,430 | $55,287,652 | -$6,405,457 | 397% | 68 |
| 2025 Q1 | 15,121,377 | $105,551,838 | -$10,223,175 | 698% | 62 |
| 2024 Q4 | 15,761,089 | $230,901,883 | +$21,882,709 | 1,465% | 60 |
| 2024 Q3 | 13,597,553 | $256,178,767 | +$9,075,038 | 1,914% | 51 |
| 2024 Q2 | 13,016,510 | $229,220,087 | +$229,145,473 | 1,761% | 49 |