| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Sectoral Asset Management Inc | 4.2% | 801K | 801K | 0 | /s/ Marina Lalakin | Marina Lalakin/Chief Compliance Officer | |
| Jerome G. Pfund | 4.99% | 951K | 951K | 0 | /s/ Jerome G. Pfund | Jerome G. Pfund |