| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 14.5% | $174M | 15.3M | ORBIMED ADVISORS LLC | May 9, 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $169M | 10.4M | RA Capital Management, L.P. | Sep 30, 2025 | |||
| BAKER BROS. ADVISORS LP | 6.9% | $107M | 7.31M | Baker Bros. Advisors LP | Jun 30, 2025 | |||
| BlackRock, Inc. | 5.5% | $89.7M | 5.82M | BlackRock, Inc. | Jun 30, 2025 | |||
| JANUS HENDERSON GROUP PLC | 4.7% | -10% | $80.8M | -$8.5M | 4.98M | -9.52% | JANUS HENDERSON GROUP PLC | Sep 30, 2025 |
| Paradigm Biocapital Advisors LP | 5% | $54.1M | 4.74M | Paradigm BioCapital Advisors LP | Jan 27, 2025 | |||
| PERCEPTIVE ADVISORS LLC | 4.4% | -28.3% | $68M | -$25.7M | 4.64M | -27.5% | Perceptive Advisors LLC | Jun 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 112M | $1.82B | -$102M | $16.22 | 170 |
| 2025 Q2 | 119M | $1.56B | +$135M | $13.11 | 177 |
| 2025 Q1 | 105M | $2.32B | +$130M | $22.00 | 190 |
| 2024 Q4 | 98.9M | $2.64B | -$77.6M | $26.70 | 196 |
| 2024 Q3 | 101M | $2.7B | -$13.8M | $26.69 | 175 |
| 2024 Q2 | 102M | $1.83B | +$179M | $18.01 | 138 |
| 2024 Q1 | 91.6M | $1.67B | +$309M | $18.24 | 125 |
| 2023 Q4 | 65.3K | $714K | +$379K | $10.94 | 2 |
| 2023 Q3 | 68.4M | $392M | -$8.24M | $5.73 | 83 |
| 2023 Q2 | 69.5M | $539M | +$23.7M | $7.75 | 93 |
| 2023 Q1 | 66.5M | $443M | -$749K | $6.67 | 85 |
| 2022 Q4 | 66.4M | $594M | +$17.7M | $8.94 | 88 |
| 2022 Q3 | 64.4M | $633M | +$133M | $9.84 | 90 |
| 2022 Q2 | 48.9M | $389M | -$30.4M | $7.96 | 72 |
| 2022 Q1 | 52.5M | $510M | +$35.1M | $9.70 | 68 |
| 2021 Q4 | 50.2M | $768M | +$33.4M | $15.28 | 56 |
| 2021 Q3 | 48M | $796M | +$3.11M | $16.60 | 47 |
| 2021 Q2 | 47.9M | $1.03B | +$40.3M | $21.33 | 46 |
| 2021 Q1 | 45.7M | $1.48B | +$1.48B | $32.50 | 31 |