| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 14.5% | 15.3M | 0 | 15.3M | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001055951 |
| ORBIMED CAPITAL GP VI LLC | 14.1% | 14.8M | 0 | 14.8M | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC (ORBIMED ADVISORS LLC, its managing member) | 0001682115 |
| OrbiMed Genesis GP LLC | 0.4% | 444K | 0 | 444K | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC (ORBIMED ADVISORS LLC, its managing member) | 0001808744 |
| ORBIMED CAPITAL LLC | 0.3% | 266K | 266K | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001157524 |