| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10% | -12% | $65,914,563 | +$10,720,599 | 7,291,434 | +19% | JANUS HENDERSON GROUP PLC | 28 Nov 2025 |
| BALYASNY ASSET MANAGEMENT L.P. | 10% | 0% | $35,820,947 | -$19,594,175 | 5,394,721 | -35% | Balyasny Asset Management L.P. | 30 Sep 2025 |
| CITADEL ADVISORS LLC | 9.6% | $25,177,009 | 5,334,112 | Kenneth Griffin | 30 Jun 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 6.9% | $33,200,000 | 5,000,000 | RA Capital Management, L.P. | 20 Oct 2025 | |||
| Affinity Asset Advisors, LLC | 7.8% | $20,069,464 | 4,252,005 | Affinity Healthcare Fund, LP | 28 May 2025 | |||
| Vestal Point Capital, LP | 7.5% | +25% | $27,338,885 | +$5,903,896 | 4,117,302 | +28% | Vestal Point Capital, LP | 30 Sep 2025 |
| Paradigm Biocapital Advisors LP | 5% | $33,047,991 | 3,671,999 | Paradigm BioCapital Advisors LP | 13 Nov 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 5.7% | $14,506,764 | 3,073,467 | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 | |||
| Longitude Capital Partners IV, LLC | 3.8% | $18,362,130 | 2,765,381 | Longitude Capital Partners IV, LLC | 30 Sep 2025 | |||
| INTEGRATED CORE STRATEGIES (US) LLC | 3.2% | -42% | $15,362,583 | -$3,470,396 | 2,313,642 | -18% | Millennium Management LLC | 30 Sep 2025 |
| MIZUHO FINANCIAL GROUP INC | 6.6% | +13% | $3,944,499 | +$496,367 | 2,203,631 | +14% | Mizuho Financial Group, Inc. | 31 Mar 2025 |
| BlackRock, Inc. | 4% | -25% | $14,368,977 | +$2,295,902 | 2,168,444 | +19% | BlackRock, Inc. | 30 Sep 2025 |
| EVENTIDE ASSET MANAGEMENT, LLC | 3.7% | $2,210,353 | 1,234,834 | Eventide Asset Management, LLC | 31 Dec 2024 | |||
| Omega Fund VI, L.P. | 3.6% | $2,120,498 | 1,184,636 | Omega Fund VI, L.P. | 31 Dec 2024 | |||
| D1 Capital Partners L.P. | 2.9% | $1,751,787 | 978,652 | D1 Capital Partners L.P. | 31 Mar 2025 | |||
| Adage Capital Management, L.P. | 0.7% | -85% | $425,936 | -$3,529,275 | 237,953 | -89% | Adage Capital Management, L.P. | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 8.4% | 6,105,527 | +66% | 0.02% | $40,492,761 |
| Frazier Life Sciences Management, L.P. | 6.1% | 4,424,725 | 0% | 0.88% | $29,380,174 |
| Balyasny Asset Management L.P. | 5.4% | 3,913,788 | -2.4% | 0.05% | $25,987,552 |
| Affinity Asset Advisors, LLC | 5.3% | 3,870,527 | +7.8% | 2.4% | $25,700,299 |
| CITADEL ADVISORS LLC | 5.1% | 3,719,043 | +3.1% | 0.02% | $24,694,446 |
| Vestal Point Capital, LP | 4.5% | 3,250,000 | +0.68% | 0.98% | $21,580,000 |
| Woodline Partners LP | 3.5% | 2,572,162 | 0% | 0.08% | $17,079,156 |
| MILLENNIUM MANAGEMENT LLC | 3.2% | 2,313,642 | -18% | 0.01% | $15,362,583 |
| VANGUARD GROUP INC | 3.1% | 2,226,290 | +11% | 0% | $14,782,566 |
| BlackRock, Inc. | 3% | 2,171,092 | +19% | 0% | $14,416,051 |
| Point72 Asset Management, L.P. | 2.7% | 1,941,849 | +200% | 0.03% | $12,893,875 |
| ADAR1 Capital Management, LLC | 2.1% | 1,531,953 | +956% | 1% | $10,172,168 |
| Blackstone Inc. | 1.5% | 1,124,922 | 0% | 0.03% | $7,469,482 |
| D1 Capital Partners L.P. | 1.3% | 978,652 | 0% | 0.07% | $6,498,249 |
| 683 Capital Management, LLC | 1.3% | 922,662 | 0.56% | $6,126,476 | |
| DIMENSIONAL FUND ADVISORS LP | 1.3% | 912,533 | +1841% | 0% | $6,059,280 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.1% | 778,611 | 0.75% | $5,169,977 | |
| GEODE CAPITAL MANAGEMENT, LLC | 0.99% | 721,881 | +25% | 0% | $4,794,441 |
| Siren, L.L.C. | 0.83% | 603,435 | 0% | 0.16% | $4,006,808 |
| Ikarian Capital, LLC | 0.78% | 567,601 | +3.2% | 0.85% | $3,768,870 |
| STATE STREET CORP | 0.75% | 544,845 | +6.2% | 0% | $3,617,771 |
| Verition Fund Management LLC | 0.57% | 414,863 | 0% | 0.02% | $2,754,690 |
| DAFNA Capital Management LLC | 0.49% | 358,083 | -5.3% | 0.59% | $2,377,671 |
| AQR CAPITAL MANAGEMENT LLC | 0.48% | 347,923 | +84% | 0% | $2,310,208 |
| UBS Group AG | 0.34% | 249,909 | -8.1% | 0% | $1,659,395 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 33,246 | $324,020 | +$186,315 | $9.93 | 4 |
| 2025 Q3 | 49,357,693 | $327,711,484 | +$52,680,419 | $6.64 | 109 |
| 2025 Q2 | 42,272,843 | $169,997,165 | +$59,022,466 | $4.02 | 90 |
| 2025 Q1 | 28,007,948 | $99,997,228 | -$11,520,761 | $3.47 | 88 |
| 2024 Q4 | 29,519,159 | $194,193,437 | -$4,086,063 | $6.58 | 89 |
| 2024 Q3 | 29,735,114 | $268,784,196 | +$10,322,369 | $9.04 | 67 |
| 2024 Q2 | 26,566,622 | $426,105,242 | +$55,254,661 | $16.04 | 57 |
| 2024 Q1 | 23,119,889 | $361,544,722 | +$108,357,037 | $15.68 | 54 |
| 2023 Q4 | 16,174,480 | $217,090,546 | +$216,963,240 | $13.42 | 31 |