| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Omega Fund VI, L.P. | 3.6% | 1,184,636 | 0 | 1,184,636 | /s/ Otello Stampacchia | Otello Stampacchia, Director of General Partner of General Partner | |
| Omega Fund VI GP, L.P. | 3.6% | 1,184,636 | 0 | 1,184,636 | /s/ Otello Stampacchia | Otello Stampacchia, Director of General Partner | |
| Omega Fund VI GP Manager, Ltd. | 3.6% | 1,184,636 | 0 | 1,184,636 | /s/ Otello Stampacchia | Otello Stampacchia, Director | |
| Claudio Nessi | 3.6% | 1,184,636 | 0 | 1,184,636 | /s/ Otello Stampacchia | Otello Stampacchia, Attorney-in-Fact | |
| Otello Stampacchia | 3.6% | 1,184,636 | 0 | 1,184,636 | /s/ Otello Stampacchia | Otello Stampacchia | |
| Francesco Draetta | 3.6% | 1,184,636 | 0 | 1,184,636 | /s/ Otello Stampacchia | Otello Stampacchia, Attorney-in-Fact |