MADRIGAL PHARMACEUTICALS, INC. - Common Stock, Par Value $0.0001 Per Share (MDGL) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2016 to Q4 2025

Type / Class
Equity / Common Stock, Par Value $0.0001 Per Share
Symbol
MDGL on Nasdaq
Shares outstanding
23,267,064
Price per share
$582.34
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
23,389,093
Total reported value
$10,723,469,698
% of total 13F portfolios
0.02%
Share change
-179,004
Value change
-$21,902,180
Number of holders
350
Price from insider filings
$582.34
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of MADRIGAL PHARMACEUTICALS, INC. - Common Stock, Par Value $0.0001 Per Share (MDGL) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
JANUS HENDERSON GROUP PLC 8.3% -16% $845,168,380 -$160,101,270 1,842,690 -16% JANUS HENDERSON GROUP PLC 30 Sep 2025
FRIEDMAN PAUL A 7.8% $1,090,767,876 1,814,831 Paul A Friedman, M.D. 10 Dec 2025
Taub Rebecca 7.8% $1,090,767,876 1,814,831 Rebecca Taub, M.D. 10 Dec 2025

As of 30 Sep 2025, 350 institutional investors reported holding 23,389,093 shares of MADRIGAL PHARMACEUTICALS, INC. - Common Stock, Par Value $0.0001 Per Share (MDGL). This represents 101% of the company’s total 23,267,064 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of MADRIGAL PHARMACEUTICALS, INC. - Common Stock, Par Value $0.0001 Per Share (MDGL) together control 80% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
BAKER BROS. ADVISORS LP 9.2% 2,141,701 +8.4% 7.1% $982,312,581
RTW INVESTMENTS, LP 8.6% 1,993,687 0% 11% $914,424,479
PAULSON & CO. INC. 8.2% 1,907,523 -8.7% 29% $874,904,499
JANUS HENDERSON GROUP PLC 7.9% 1,842,690 -16% 0.39% $845,277,273
Avoro Capital Advisors LLC 7.9% 1,833,000 -2.2% 11% $840,723,780
VANGUARD GROUP INC 7.8% 1,812,054 -3.5% 0.01% $831,116,688
BlackRock, Inc. 6.7% 1,559,712 +8.4% 0.01% $715,377,705
STATE STREET CORP 2.8% 658,097 -4.7% 0.01% $301,842,770
GEODE CAPITAL MANAGEMENT, LLC 1.9% 446,233 +7.7% 0.01% $204,700,716
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 1.8% 411,802 +18% 0.49% $188,877,105
WELLINGTON MANAGEMENT GROUP LLP 1.7% 404,455 +5381% 0.03% $185,507,331
FMR LLC 1.7% 401,136 -9.9% 0.01% $183,985,076
GOLDMAN SACHS GROUP INC 1.7% 386,100 +103% 0.03% $177,088,626
PRICE T ROWE ASSOCIATES INC /MD/ 1.5% 352,520 -31% 0.02% $161,688,000
Invesco Ltd. 1.3% 299,565 +50% 0.02% $137,398,483
Polar Capital Holdings Plc 1.1% 265,154 +18% 0.59% $121,615,534
MORGAN STANLEY 1.1% 249,647 +0.68% 0.01% $114,503,407
BANK OF AMERICA CORP /DE/ 1% 244,292 -12% 0.01% $112,046,969
Hood River Capital Management LLC 1% 242,808 -0.79% 1.3% $111,366,317
UBS Group AG 0.93% 217,343 -57% 0.02% $99,686,540
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.92% 213,652 +40% 0.02% $97,993,626
Artisan Partners Limited Partnership 0.89% 206,254 +2.3% 0.14% $94,600,460
Erste Asset Management GmbH 0.86% 201,100 0% 0.86% $89,107,410
Pictet Asset Management Holding SA 0.82% 191,796 -7.9% 0.08% $87,710,002
AMERICAN CENTURY COMPANIES INC 0.71% 165,615 -1.3% 0.04% $75,961,972

Institutional Holders of MADRIGAL PHARMACEUTICALS, INC. - Common Stock, Par Value $0.0001 Per Share (MDGL) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 75,590 $43,957,702 -$1,621,287 $582.34 35
2025 Q3 23,389,093 $10,723,469,698 -$21,902,180 $458.66 350
2025 Q2 23,552,943 $7,127,866,991 -$58,976,544 $302.64 303
2025 Q1 23,618,790 $7,815,273,691 +$242,480,081 $331.23 317
2024 Q4 22,950,912 $7,082,777,476 +$148,808,606 $308.57 281
2024 Q3 22,565,190 $4,747,522,154 -$129,510,961 $212.22 258
2024 Q2 22,866,470 $6,407,124,653 +$529,653,040 $280.16 263
2024 Q1 21,016,048 $5,610,215,470 +$313,517,433 $267.04 274
2023 Q4 338,003 $78,350,684 +$16,320,496 $231.60 2
2023 Q3 16,984,543 $2,480,570,984 +$299,597,422 $146.04 204
2023 Q2 14,673,698 $3,389,232,492 +$194,935,522 $231.00 205
2023 Q1 13,856,567 $3,356,780,128 +$106,375,328 $242.26 220
2022 Q4 13,282,227 $3,855,196,101 +$562,845,147 $290.25 184
2022 Q3 11,741,760 $763,152,205 -$25,138,799 $64.99 132
2022 Q2 12,001,137 $857,568,681 -$17,312,280 $71.58 130
2022 Q1 12,017,683 $1,179,075,073 +$28,333,447 $98.12 131
2021 Q4 11,925,872 $1,009,835,597 +$43,052,265 $84.74 138
2021 Q3 10,950,378 $874,177,601 -$34,123,130 $79.79 129
2021 Q2 11,229,236 $1,093,866,439 -$100,446,690 $97.41 147
2021 Q1 12,210,464 $1,427,896,568 -$10,188,462 $116.97 135
2020 Q4 12,273,522 $1,364,432,852 +$68,888,247 $111.17 132
2020 Q3 11,627,623 $1,380,547,563 +$47,849,188 $118.73 124
2020 Q2 11,257,505 $1,274,820,026 +$4,837,561 $113.25 124
2020 Q1 11,044,574 $737,327,931 +$26,596,104 $66.76 102
2019 Q4 10,473,736 $954,260,097 +$66,209,869 $91.11 118
2019 Q3 9,616,500 $829,112,218 -$305,654 $86.22 105
2019 Q2 9,600,815 $1,006,174,218 +$18,546,109 $104.81 112
2019 Q1 9,450,861 $1,183,534,615 +$61,310,849 $125.26 129
2018 Q4 8,980,924 $1,012,208,421 -$4,920,541 $112.72 129
2018 Q3 8,566,494 $1,834,453,035 +$66,978,782 $214.13 150
2018 Q2 8,030,867 $2,244,730,050 +$567,838,949 $279.69 144
2018 Q1 6,326,066 $738,819,669 +$153,237,677 $116.79 97
2017 Q4 5,126,527 $469,043,087 +$232,621,151 $91.79 87
2017 Q3 2,673,023 $120,233,767 +$29,371,608 $44.98 48
2017 Q2 2,031,780 $33,036,795 +$8,648,547 $16.26 35
2017 Q1 1,527,086 $23,515,000 +$2,997,259 $15.40 23
2016 Q4 1,345,538 $20,048,000 +$6,295,663 $14.90 23
2016 Q3 1,006,834 $12,764,000 +$12,736,979 $12.67 23
2016 Q2 79,573 $21,000 +$20,999 $0.26 1