| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 10% | +8.8% | $89,563,080 | +$22,127,178 | 8,729,345 | +33% | VIKING GLOBAL INVESTORS LP | 30 Jun 2025 |
| Nextech Crossover I GP S.a r.l. | 8.4% | $73,488,656 | 7,162,637 | Nextech Crossover I GP S.a. r.l. | 30 Jun 2025 | |||
| EcoR1 Capital, LLC | 6.9% | $35,726,296 | 6,728,116 | EcoR1 Capital, LLC | 29 Jul 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 7.7% | +64% | $35,029,459 | +$18,130,241 | 6,596,885 | +107% | Venrock Healthcare Capital Partners III, L.P. | 08 Apr 2025 |
| SR ONE CAPITAL MANAGEMENT, LLC | 4.8% | -13% | $47,353,840 | 4,615,384 | 0% | SR One Capital Management, LLC | 12 Aug 2025 | |
| ALKEON CAPITAL MANAGEMENT LLC | 4.6% | $54,049,152 | 4,504,096 | Alkeon Capital Management LLC | 30 Sep 2025 | |||
| Point72 Asset Management, L.P. | 5.1% | $45,161,021 | 4,401,659 | Point72 Asset Management, L.P. | 29 May 2025 | |||
| COLUMN GROUP II, LP | 3.7% | $48,612,534 | 3,644,118 | Peter Svennilson | 30 Sep 2025 | |||
| BlackRock, Inc. | 4.2% | $19,223,389 | 3,620,224 | BlackRock, Inc. | 30 Jun 2025 | |||
| FMR LLC | 3.5% | $12,141,619 | 2,467,809 | FMR LLC | 31 Dec 2024 | |||
| Frazier Life Sciences Public Fund, L.P. | 2% | $6,938,150 | 1,410,193 | James N. Topper | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Nextech Invest, Ltd. | 7.3% | 7,162,637 | 0% | 13% | $85,951,644 |
| EcoR1 Capital, LLC | 6.8% | 6,728,116 | +316% | 3.9% | $80,737,392 |
| VR ADVISER, LLC | 6.7% | 6,596,885 | 0% | 4.5% | $79,162,620 |
| VIKING GLOBAL INVESTORS LP | 6.7% | 6,572,700 | 0% | 0.2% | $78,872,400 |
| Pfizer Inc | 5.5% | 5,376,344 | 0% | 15% | $64,516,128 |
| BlackRock, Inc. | 5.4% | 5,276,620 | +29% | 0% | $63,319,440 |
| VANGUARD GROUP INC | 4.7% | 4,650,138 | +49% | 0% | $55,801,656 |
| SR One Capital Management, LP | 4.6% | 4,514,929 | 0% | 7.8% | $54,179,148 |
| ALKEON CAPITAL MANAGEMENT LLC | 4.6% | 4,504,096 | 0% | 0.24% | $54,049,152 |
| NEA Management Company, LLC | 4.2% | 4,118,621 | 0% | 2.7% | $49,423,452 |
| ORBIMED ADVISORS LLC | 3.7% | 3,641,756 | +305% | 1% | $43,701,072 |
| Column Group LLC | 3.6% | 3,540,777 | 0% | 52% | $42,489,324 |
| Vivo Capital, LLC | 3.2% | 3,126,604 | 0% | 3% | $37,519,248 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.9% | 2,871,327 | +3.9% | 0% | $34,457,000 |
| Point72 Asset Management, L.P. | 2.7% | 2,619,914 | -8.1% | 0.07% | $31,438,968 |
| FMR LLC | 2.6% | 2,528,048 | +2.3% | 0% | $30,336,576 |
| STATE STREET CORP | 2.4% | 2,403,939 | +47% | 0% | $28,847,268 |
| First Turn Management, LLC | 2.2% | 2,159,474 | +7.4% | 3.9% | $25,913,688 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2% | 1,948,808 | +8.2% | 3.4% | $23,385,696 |
| MPM BIOIMPACT LLC | 1.8% | 1,729,378 | 0% | 3.4% | $20,752,536 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 1,630,744 | +47% | 0% | $19,573,783 |
| Balyasny Asset Management L.P. | 1.5% | 1,519,314 | -15% | 0.04% | $18,231,768 |
| ROYCE & ASSOCIATES LP | 1.5% | 1,458,483 | +521% | 0.17% | $17,501,796 |
| JPMORGAN CHASE & CO | 1.2% | 1,228,528 | -8% | 0% | $14,742,336 |
| CITADEL ADVISORS LLC | 1.2% | 1,198,004 | -15% | 0.01% | $14,376,048 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 42,239 | $346,005 | +$47,889 | 818.09% | 3 |
| 2025 Q3 | 106,492,098 | $1,277,897,890 | +$159,574,070 | 1,200% | 151 |
| 2025 Q2 | 93,349,298 | $947,499,065 | +$169,716,846 | 1,015% | 140 |
| 2025 Q1 | 79,209,337 | $442,005,240 | +$11,923,653 | 558% | 142 |
| 2024 Q4 | 75,794,185 | $611,682,286 | -$16,308,142 | 807% | 129 |
| 2024 Q3 | 69,823,199 | $715,076,222 | +$22,599,735 | 1,025% | 121 |
| 2024 Q2 | 67,581,249 | $477,801,725 | +$16,918,129 | 707% | 111 |
| 2024 Q1 | 61,522,206 | $845,930,302 | +$182,999,091 | 1,375% | 93 |
| 2023 Q4 | 16,457 | $151,404 | -$189,662 | 920% | 1 |
| 2023 Q3 | 48,053,106 | $290,723,330 | +$14,140,743 | 605% | 89 |
| 2023 Q2 | 45,537,877 | $353,374,807 | +$99,053,472 | 776% | 83 |
| 2023 Q1 | 33,075,099 | $188,527,951 | +$3,379,925 | 570% | 70 |
| 2022 Q4 | 32,430,291 | $192,141,081 | -$463,484 | 589% | 64 |
| 2022 Q3 | 32,701,288 | $104,643,704 | -$1,676,650 | 320% | 69 |
| 2022 Q2 | 32,836,960 | $147,125,000 | -$5,569,766 | 448% | 75 |
| 2022 Q1 | 31,462,589 | $167,970,917 | -$6,985,117 | 534% | 91 |
| 2021 Q4 | 32,408,019 | $476,115,938 | -$54,519,859 | 1,470% | 75 |
| 2021 Q3 | 36,405,513 | $761,744,855 | +$8,529,738 | 2,091% | 80 |
| 2021 Q2 | 36,145,561 | $639,409,737 | -$3,016,892 | 1,769% | 78 |
| 2021 Q1 | 34,481,967 | $844,794,848 | +$63,249,843 | 2,449.98% | 81 |
| 2020 Q4 | 32,486,547 | $1,099,708,951 | +$273,809,943 | 3,385% | 74 |
| 2020 Q3 | 22,151,946 | $552,858,000 | +$7,639,740 | 2,500.85% | 52 |
| 2020 Q2 | 21,388,813 | $718,339,063 | +$718,339,299 | 3,373% | 64 |