| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 12% | -7.9% | $161,328,840 | -$12,876,238 | 6,865,057 | -7.4% | FMR LLC | 30 Sep 2025 |
| RTW INVESTMENTS, LP | 10% | $37,276,432 | 5,310,033 | RTW Investments, LP | 31 Dec 2024 | |||
| Redmile Group, LLC | 8% | $86,512,156 | 4,375,931 | Redmile Group, LLC | 30 Jun 2025 | |||
| BlackRock, Inc. | 6.8% | +17% | $87,769,558 | +$14,428,761 | 3,732,540 | +20% | BlackRock, Inc. | 30 Sep 2025 |
| MORGAN STANLEY | 6.5% | $24,055,708 | 3,426,739 | Morgan Stanley | 31 Dec 2024 | |||
| TORONTO DOMINION BANK | 5.8% | $74,571,563 | 3,173,258 | The Toronto-Dominion Bank | 30 Sep 2025 | |||
| BlackRock Portfolio Management LLC | 4.7% | -8% | $22,774,545 | -$1,724,928 | 2,550,341 | -7% | BlackRock Portfolio Management LLC | 30 Jun 2025 |
| Skorpios Trust | 4.1% | -32% | $44,604,698 | -$19,770,000 | 2,256,181 | -31% | Montrago Trustees Ltd | 22 Aug 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 830 | $26,344 | +$4,761 | $31.74 | 1 |
| 2025 Q3 | 67,696,992 | $1,574,192,573 | +$64,455,996 | $23.50 | 149 |
| 2025 Q2 | 65,548,147 | $743,993,162 | +$30,166,676 | $11.35 | 133 |
| 2025 Q1 | 63,384,229 | $421,575,432 | +$30,343,493 | $6.65 | 124 |
| 2024 Q4 | 58,062,255 | $640,428,134 | -$5,638,099 | $11.03 | 129 |
| 2024 Q3 | 58,214,468 | $715,466,933 | -$45,807,233 | $12.29 | 117 |
| 2024 Q2 | 61,304,681 | $828,225,320 | +$97,136,902 | $13.51 | 115 |
| 2024 Q1 | 54,088,556 | $730,193,367 | +$114,215,269 | $13.50 | 103 |
| 2023 Q4 | 11,175 | $58,781 | $5.26 | 1 | |
| 2023 Q3 | 43,943,299 | $173,133,718 | -$18,218,100 | $3.94 | 96 |
| 2023 Q2 | 46,509,311 | $494,393,987 | +$20,745,423 | $10.63 | 96 |
| 2023 Q1 | 44,634,775 | $371,806,873 | +$14,235,475 | $8.33 | 96 |
| 2022 Q4 | 40,279,912 | $371,786,295 | -$19,239,520 | $9.23 | 105 |
| 2022 Q3 | 38,881,653 | $499,249,939 | +$1,438,369 | $12.84 | 95 |
| 2022 Q2 | 40,447,319 | $534,718,611 | +$3,680,151 | $13.21 | 84 |
| 2022 Q1 | 38,782,270 | $816,581,369 | +$73,042,082 | $21.05 | 95 |
| 2021 Q4 | 35,373,861 | $848,353,238 | +$26,367,072 | $23.99 | 90 |
| 2021 Q3 | 19,344,769 | $492,131,865 | -$27,772,629 | $25.44 | 88 |
| 2021 Q2 | 20,207,425 | $680,021,758 | -$703,083,717 | $33.66 | 96 |
| 2021 Q1 | 38,413,301 | $1,491,946,127 | -$15,735,711 | $38.84 | 104 |
| 2020 Q4 | 38,384,996 | $2,377,144,958 | +$253,209,485 | $61.93 | 90 |
| 2020 Q3 | 34,632,372 | $1,159,842,494 | +$2,937,873 | $33.49 | 89 |
| 2020 Q2 | 34,945,208 | $824,516,432 | +$9,797,076 | $23.83 | 69 |
| 2020 Q1 | 34,556,673 | $791,346,895 | +$23,316,443 | $22.90 | 65 |
| 2019 Q4 | 33,480,528 | $948,106,901 | +$22,388,815 | $28.32 | 63 |
| 2019 Q3 | 15,935,472 | $338,961,585 | +$30,077,160 | $21.49 | 52 |
| 2019 Q2 | 14,186,934 | $408,011,450 | +$408,011,278 | $29.17 | 46 |