| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 12% | -7.9% | $161,328,840 | -$12,876,238 | 6,865,057 | -7.4% | FMR LLC | 30 Sep 2025 |
| RTW INVESTMENTS, LP | 10% | $37,276,432 | 5,310,033 | RTW Investments, LP | 31 Dec 2024 | |||
| Redmile Group, LLC | 8% | $86,512,156 | 4,375,931 | Redmile Group, LLC | 30 Jun 2025 | |||
| BlackRock, Inc. | 6.8% | +17% | $87,769,558 | +$14,428,761 | 3,732,540 | +20% | BlackRock, Inc. | 30 Sep 2025 |
| MORGAN STANLEY | 6.5% | $24,055,708 | 3,426,739 | Morgan Stanley | 31 Dec 2024 | |||
| TORONTO DOMINION BANK | 5.8% | $74,571,563 | 3,173,258 | The Toronto-Dominion Bank | 30 Sep 2025 | |||
| BlackRock Portfolio Management LLC | 4.7% | -8% | $22,774,545 | -$1,724,928 | 2,550,341 | -7% | BlackRock Portfolio Management LLC | 30 Jun 2025 |
| Skorpios Trust | 4.1% | -32% | $44,604,698 | -$19,770,000 | 2,256,181 | -31% | Montrago Trustees Ltd | 22 Aug 2025 |
As of 30 Sep 2025, 149 institutional investors reported holding 67,696,992 shares of Stoke Therapeutics, Inc. - Common Stock, $0.0001 par value per share (STOK). This represents 124% of the company’s total 54,711,345 outstanding shares.
The largest institutional shareholders of Stoke Therapeutics, Inc. - Common Stock, $0.0001 par value per share (STOK) together control 111% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 13% | 6,865,057 | -7.4% | 0.01% | $161,328,840 |
| BlackRock, Inc. | 11% | 5,987,441 | +1.1% | 0% | $140,704,869 |
| Lynx1 Capital Management LP | 9.9% | 5,404,674 | 0% | 22% | $109,881,253 |
| RTW INVESTMENTS, LP | 9.4% | 5,123,525 | 0% | 1.5% | $120,402,838 |
| BAKER BROS. ADVISORS LP | 8.5% | 4,633,838 | 0% | 0.79% | $108,895,193 |
| Redmile Group, LLC | 7.6% | 4,175,542 | -4.6% | 9.5% | $98,125,237 |
| MORGAN STANLEY | 6.5% | 3,537,050 | -1% | 0.01% | $83,120,676 |
| TORONTO DOMINION BANK | 5.8% | 3,173,258 | 0% | 0.14% | $74,571,563 |
| VANGUARD GROUP INC | 5.8% | 3,163,874 | +7.4% | 0% | $74,351,040 |
| Skorpios Trust | 4.1% | 2,256,181 | -31% | 100% | $53,020,254 |
| Siren, L.L.C. | 4.1% | 2,247,347 | 0% | 2.1% | $52,812,655 |
| BVF INC/IL | 3% | 1,657,096 | 1.6% | $38,941,756 | |
| STATE STREET CORP | 2.6% | 1,425,873 | -4.1% | 0% | $33,508,016 |
| Polar Capital Holdings Plc | 2.4% | 1,323,470 | +50% | 0.15% | $31,101,545 |
| Point72 Asset Management, L.P. | 2.4% | 1,306,698 | 0.07% | $30,707,403 | |
| GOLDMAN SACHS GROUP INC | 2.1% | 1,150,929 | -12% | 0% | $27,046,832 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.1% | 1,147,000 | +18% | 0% | $26,959,632 |
| ROYAL BANK OF CANADA | 1.7% | 915,785 | +536% | 0% | $21,521,000 |
| Assenagon Asset Management S.A. | 1.6% | 900,272 | +67% | 0.03% | $21,156,392 |
| MPM BIOIMPACT LLC | 1.4% | 789,698 | 0% | 3% | $18,557,903 |
| MARSHALL WACE, LLP | 1.4% | 768,287 | -67% | 0.02% | $18,054,745 |
| WELLINGTON MANAGEMENT GROUP LLP | 1.3% | 737,753 | +438% | 0% | $17,337,197 |
| Opaleye Management Inc. | 1.2% | 682,017 | +21% | 2.3% | $16,027,400 |
| DIMENSIONAL FUND ADVISORS LP | 1.2% | 678,307 | +0.66% | 0% | $15,946,030 |
| TANG CAPITAL MANAGEMENT LLC | 0.91% | 500,000 | 0% | 0.45% | $11,750,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 1,255,985 | $39,864,929 | +$10,932,536 | $31.74 | 5 |
| 2025 Q3 | 67,696,992 | $1,574,192,573 | +$64,455,996 | $23.50 | 149 |
| 2025 Q2 | 65,548,147 | $743,993,162 | +$30,166,676 | $11.35 | 133 |
| 2025 Q1 | 63,384,229 | $421,575,432 | +$30,343,493 | $6.65 | 124 |
| 2024 Q4 | 58,062,255 | $640,428,134 | -$5,638,099 | $11.03 | 129 |
| 2024 Q3 | 58,214,468 | $715,466,933 | -$45,807,233 | $12.29 | 117 |
| 2024 Q2 | 61,304,681 | $828,225,320 | +$97,136,902 | $13.51 | 115 |
| 2024 Q1 | 54,088,556 | $730,193,367 | +$114,215,269 | $13.50 | 103 |
| 2023 Q4 | 11,175 | $58,781 | $5.26 | 1 | |
| 2023 Q3 | 43,943,299 | $173,133,718 | -$18,218,100 | $3.94 | 96 |
| 2023 Q2 | 46,509,311 | $494,393,987 | +$20,745,423 | $10.63 | 96 |
| 2023 Q1 | 44,634,775 | $371,806,873 | +$14,235,475 | $8.33 | 96 |
| 2022 Q4 | 40,279,912 | $371,786,295 | -$19,239,520 | $9.23 | 105 |
| 2022 Q3 | 38,881,653 | $499,249,939 | +$1,438,369 | $12.84 | 95 |
| 2022 Q2 | 40,447,319 | $534,718,611 | +$3,680,151 | $13.21 | 84 |
| 2022 Q1 | 38,782,270 | $816,581,369 | +$73,042,082 | $21.05 | 95 |
| 2021 Q4 | 35,373,861 | $848,353,238 | +$26,367,072 | $23.99 | 90 |
| 2021 Q3 | 19,344,769 | $492,131,865 | -$27,772,629 | $25.44 | 88 |
| 2021 Q2 | 20,207,425 | $680,021,758 | -$703,083,717 | $33.66 | 96 |
| 2021 Q1 | 38,413,301 | $1,491,946,127 | -$15,735,711 | $38.84 | 104 |
| 2020 Q4 | 38,384,996 | $2,377,144,958 | +$253,209,485 | $61.93 | 90 |
| 2020 Q3 | 34,632,372 | $1,159,842,494 | +$2,937,873 | $33.49 | 89 |
| 2020 Q2 | 34,945,208 | $824,516,432 | +$9,797,076 | $23.83 | 69 |
| 2020 Q1 | 34,556,673 | $791,346,895 | +$23,316,443 | $22.90 | 65 |
| 2019 Q4 | 33,480,528 | $948,106,901 | +$22,388,815 | $28.32 | 63 |
| 2019 Q3 | 15,935,472 | $338,961,585 | +$30,077,160 | $21.49 | 52 |
| 2019 Q2 | 14,186,934 | $408,011,450 | +$408,011,278 | $29.17 | 46 |