| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RTW Investments, LP | 10% | 5,310,033 | 0 | 5,310,033 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Managing Partner | |
| Roderick Wong, M.D. | 10% | 5,310,033 | 0 | 5,310,033 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D. |