| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 12% | +12% | $316,353,414 | +$34,891,550 | 8,824,363 | +12% | FMR LLC | 30 Jun 2025 |
| BlackRock, Inc. | 6.2% | $170,563,868 | 4,757,709 | BlackRock, Inc. | 30 Jun 2025 | |||
| JANUS HENDERSON GROUP PLC | 5.1% | $158,346,983 | 3,943,885 | JANUS HENDERSON GROUP PLC | 30 Sep 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 2.8% | $68,070,019 | 2,174,761 | Wellington Management Group LLP | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 12% | 8,918,907 | +0.39% | 0.02% | $358,094,116 |
| Avoro Capital Advisors LLC | 7% | 5,400,000 | 0% | 2.8% | $216,810,000 |
| BlackRock, Inc. | 6.2% | 4,770,951 | -11% | 0% | $191,553,697 |
| Driehaus Capital Management LLC | 5.4% | 4,169,114 | -3.8% | 1.2% | $167,389,927 |
| JANUS HENDERSON GROUP PLC | 5.1% | 3,943,885 | +10% | 0.07% | $158,311,659 |
| WELLINGTON MANAGEMENT GROUP LLP | 4.7% | 3,609,857 | +66% | 0.03% | $144,935,758 |
| BRAIDWELL LP | 4.7% | 3,605,029 | 0% | 4.3% | $144,741,914 |
| Capital International Investors | 4.1% | 3,181,493 | -0% | 0.02% | $127,736,944 |
| Commodore Capital LP | 3.5% | 2,700,000 | -11% | 5.3% | $108,405,000 |
| Polar Capital Holdings Plc | 3.3% | 2,546,766 | -5.8% | 0.49% | $102,252,655 |
| Holocene Advisors, LP | 2.6% | 1,976,553 | +9.2% | 0.18% | $79,358,603 |
| ALLIANCEBERNSTEIN L.P. | 2.1% | 1,654,417 | +8.9% | 0.02% | $66,424,843 |
| STATE STREET CORP | 1.9% | 1,466,467 | +6.2% | 0% | $58,878,650 |
| Affinity Asset Advisors, LLC | 1.8% | 1,400,000 | +27% | 5.2% | $56,210,000 |
| JPMORGAN CHASE & CO | 1.8% | 1,399,033 | +11% | 0% | $56,171,175 |
| MILLENNIUM MANAGEMENT LLC | 1.8% | 1,384,007 | +57% | 0.04% | $55,567,881 |
| Pictet Asset Management Holding SA | 1.6% | 1,262,579 | -14% | 0.05% | $50,584,462 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1.6% | 1,206,066 | +4.6% | 0.2% | $48,423,550 |
| Deep Track Capital, LP | 1.6% | 1,200,000 | -11% | 1.3% | $48,180,000 |
| JENNISON ASSOCIATES LLC | 1.5% | 1,135,235 | +63% | 0.03% | $45,579,686 |
| Vestal Point Capital, LP | 1.4% | 1,100,000 | -45% | 2% | $44,165,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3% | 977,435 | +0.73% | 0% | $39,240,615 |
| CITADEL ADVISORS LLC | 1.2% | 959,098 | +699% | 0.03% | $38,507,785 |
| Rock Springs Capital Management LP | 1.1% | 851,744 | -8.6% | 2% | $34,197,522 |
| VANGUARD GROUP INC | 1.1% | 851,386 | -2.5% | 0% | $34,183,148 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 137,311 | $6,154,088 | +$4,482,677 | $44.82 | 6 |
| 2025 Q3 | 84,318,823 | $3,385,111,233 | +$50,758,243 | $40.15 | 217 |
| 2025 Q2 | 83,131,091 | $2,602,180,922 | +$191,395,529 | $31.30 | 206 |
| 2025 Q1 | 76,712,487 | $2,576,155,081 | +$10,185,348 | $33.55 | 206 |
| 2024 Q4 | 76,288,487 | $2,990,360,179 | +$29,951,117 | $39.20 | 208 |
| 2024 Q3 | 74,874,891 | $2,948,970,026 | +$110,226 | $39.37 | 203 |
| 2024 Q2 | 74,159,245 | $2,891,332,046 | +$26,539,830 | $38.99 | 211 |
| 2024 Q1 | 73,470,358 | $3,162,898,574 | +$59,102,723 | $43.05 | 219 |
| 2023 Q4 | 138,940 | $6,411,576 | +$1,698,608 | $46.06 | 3 |
| 2023 Q3 | 61,316,223 | $2,094,590,805 | +$2,759,485 | $34.16 | 178 |
| 2023 Q2 | 61,255,932 | $2,358,691,186 | +$10,271,230 | $38.50 | 171 |
| 2023 Q1 | 61,098,066 | $2,184,642,437 | +$26,598,092 | $35.79 | 159 |
| 2022 Q4 | 60,364,635 | $2,380,155,366 | +$39,315,554 | $39.43 | 155 |
| 2022 Q3 | 56,652,467 | $2,045,142,623 | +$60,186,774 | $36.10 | 147 |
| 2022 Q2 | 56,972,759 | $1,733,113,951 | +$241,066,358 | $30.42 | 148 |
| 2022 Q1 | 49,007,746 | $1,498,193,380 | +$44,977,694 | $30.57 | 126 |
| 2021 Q4 | 47,654,350 | $1,488,726,712 | +$452,311,689 | $31.24 | 128 |
| 2021 Q3 | 34,091,198 | $521,377,671 | +$393,910 | $15.28 | 115 |
| 2021 Q2 | 33,294,296 | $619,929,580 | +$2,294,891 | $18.62 | 98 |
| 2021 Q1 | 32,940,149 | $589,578,963 | +$88,729,048 | $17.90 | 88 |
| 2020 Q4 | 27,990,190 | $430,443,842 | -$1,905,169 | $15.38 | 78 |
| 2020 Q3 | 27,927,587 | $309,203,900 | -$545,966 | $11.07 | 79 |
| 2020 Q2 | 27,956,808 | $350,579,052 | +$8,433,273 | $12.54 | 77 |
| 2020 Q1 | 27,692,215 | $313,869,842 | +$101,491,026 | $11.34 | 69 |
| 2019 Q4 | 18,658,224 | $244,608,634 | +$22,906,546 | $13.11 | 65 |
| 2019 Q3 | 16,092,590 | $144,974,637 | -$14,676,521 | $9.01 | 52 |
| 2019 Q2 | 17,561,058 | $173,154,992 | -$1,930,170 | $9.86 | 57 |
| 2019 Q1 | 17,733,113 | $180,170,294 | +$3,705,615 | $10.16 | 60 |
| 2018 Q4 | 17,450,658 | $110,112,206 | -$23,321,684 | $6.31 | 56 |
| 2018 Q3 | 17,678,662 | $233,174,834 | +$113,990,255 | $13.20 | 59 |
| 2018 Q2 | 9,020,019 | $82,987,000 | +$29,134,582 | $9.20 | 40 |
| 2018 Q1 | 6,342,246 | $31,075,772 | -$13,812,197 | $4.90 | 34 |
| 2017 Q4 | 9,156,533 | $25,870,000 | -$498,228 | $2.83 | 30 |
| 2017 Q3 | 9,321,689 | $27,499,000 | -$1,982,221 | $2.95 | 30 |
| 2017 Q2 | 9,944,887 | $31,325,000 | -$1,129,729 | $3.15 | 37 |
| 2017 Q1 | 10,076,383 | $40,304,000 | -$3,235,784 | $4.00 | 36 |
| 2016 Q4 | 10,492,956 | $80,798,000 | +$2,074,527 | $7.70 | 31 |
| 2016 Q3 | 9,927,644 | $80,212,203 | +$36,798,916 | $8.10 | 30 |
| 2016 Q2 | 5,377,405 | $32,047,000 | -$2,511,469 | $5.90 | 20 |
| 2016 Q1 | 5,691,967 | $39,789,000 | -$1,434,188 | $6.99 | 24 |
| 2015 Q4 | 5,760,092 | $46,313,000 | +$2,273,762 | $8.04 | 24 |
| 2015 Q3 | 5,349,369 | $44,185,000 | +$5,122,968 | $8.26 | 24 |
| 2015 Q2 | 4,679,033 | $53,949,000 | +$3,173,785 | $11.53 | 24 |
| 2015 Q1 | 4,449,844 | $75,166,316 | +$2,920,395 | $16.86 | 23 |
| 2014 Q4 | 4,275,072 | $83,141,000 | +$74,135,921 | $19.75 | 16 |