- 
        Signature
      
 
      - 
        /s/ Darin Lippoldt, Attorney-in-Fact
      
 
    
    
      
- 
        Stock symbol
      
 
      - 
        NBIX
      
 
    
    
      
- 
        Transactions as of
      
 
      - 
        May 5, 2025
      
 
    
    
      
- 
        Transactions value $
      
 
      - 
        -$2,023,152
      
 
    
    
      
- 
        Form type
      
 
      - 
        4
      
 
    
    
      
- 
        Date filed
      
 
      - 
        5/7/2025, 07:05 PM
      
 
    
    
    
    
   
     
   
 
  
    Reporting Owners (1)
  
  
    
      
        
          | Name | 
          Relationship | 
          Address | 
          Signature | 
          Signature date | 
          CIK | 
        
      
      
          
            | RASTETTER WILLIAM H | 
            Director | 
            6027 EDGEWOOD BEND COURT, SAN DIEGO | 
            /s/ Darin Lippoldt, Attorney-in-Fact | 
            2025-05-07 | 
            0001205903 | 
          
      
    
   
  
    Transactions Table
  
  
    
      
        
          | Type | 
          Sym | 
          Class | 
          Transaction | 
          Value $ | 
          Shares | 
          Change % | 
          * Price $ | 
          Shares After | 
          Date | 
          Ownership | 
          Footnotes | 
        
      
      
          
            | transaction | 
            NBIX | 
            Common Stock | 
            Options Exercise | 
            $1.28M | 
            +30K | 
            +80.02% | 
            $42.76 | 
            67.5K | 
            May 5, 2025 | 
            Direct | 
             | 
          
          
            | transaction | 
            NBIX | 
            Common Stock | 
            Sale | 
            -$3.31M | 
            -30K | 
            -44.45% | 
            $110.20 | 
            37.5K | 
            May 5, 2025 | 
            Direct | 
            F1, F2, F3 | 
          
      
    
   
  
    Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)
  
  
    
      
        
          | Type | 
          Sym | 
          Class | 
          Transaction | 
          Value $ | 
          Shares | 
          Change % | 
          * Price $ | 
          Shares After | 
          Date | 
          Underlying Class | 
          Amount | 
          Exercise Price | 
          Ownership | 
          Footnotes | 
        
      
      
          
            | transaction | 
            NBIX | 
            Non-Qualified Stock Option | 
            Options Exercise | 
            $0 | 
            -30K | 
            -100% | 
            $0.00 | 
            0 | 
            May 5, 2025 | 
            Common Stock | 
            30K | 
            $42.76 | 
            Direct | 
            F4 | 
          
      
    
   
  
    * An asterisk sign (*) next to the price indicates that the price is likely invalid.
  
  Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
  Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
  
    Explanation of Responses: