| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Duarte Ira | EVP, Chief Financial Officer | 100 REGENCY FOREST DRIVE, SUITE 300, CARY | /s/Kathryn Lester Attorney-in-fact for Ira Duarte | 2025-08-04 | 0001488864 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Common Stock | Options Exercise | +11.7K | +7.67% | 164K | Jul 31, 2025 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Restricted Stock Units | Options Exercise | $0 | -11.7K | -6.67% | $0.00 | 164K | Jul 31, 2025 | Common Stock | 11.7K | $0.00 | Direct | F2, F3 |
| Id | Content |
|---|---|
| F1 | Each restricted stock unit represents a contingent right to receive one share of common stock. |
| F2 | The number of restricted stock units disclosed on the Reporting Person's Form 4 filed on April 22, 2025, May 2, 2025 and June 17 , 2025 ("Affected Form 4 Filings") were erroneously disclosed as an acquisition in Column 5(A) when it should have been disclosed as a disposition in Column 5(D). All other information in the Affected Form 4 Filings is correct. |
| F3 | The restricted stock units vest in 16 equal installments beginning one quarter after the date of grant (January 31, 2025). |