| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Duarte Ira | EVP, Chief Financial Officer | 100 REGENCY FOREST DRIVE, SUITE 300, CARY | /s/Kathryn Lester Attorney-in-fact for Ira Duarte | 2025-10-21 | 0001488864 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Common Stock | Options Exercise | +3.87K | +2.36% | 168K | Oct 19, 2025 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Restricted Stock Units | Options Exercise | $0 | -3.87K | -10% | $0.00 | 34.9K | Oct 19, 2025 | Common Stock | 3.87K | $0.00 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | Each restricted stock unit represents a contingent right to receive one share of common stock. |
| F2 | The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (01/19/2024). |