| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Duarte Ira | EVP, Chief Financial Officer | 100 REGENCY FOREST DRIVE, SUITE 300, CARY | /s/Kathryn Lester Attorney-in-fact for Ira Duarte | 2025-11-04 | 0001488864 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Common Stock | Options Exercise | +11.7K | +6.96% | 180K | Oct 31, 2025 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Restricted Stock Units | Options Exercise | $0 | -11.7K | -7.14% | $0.00 | 152K | Oct 31, 2025 | Common Stock | 11.7K | $0.00 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | Each restricted stock unit represents a contingent right to receive one share of common stock. |
| F2 | The restricted stock units vest in 16 equal installments beginning one quarter after the date of grant (January 31, 2025). |