Third Rock Ventures IV, L.P. - Oct 23, 2025 Form 4 Insider Report for Tango Therapeutics, Inc. (TNGX)

Role: 10%+ Owner
Signature: /s/ Kevin Gillis, Chief Operating Officer of TRV GP IV, LLC, general partner of Third Rock Ventures GP IV, L.P., general partner of Third Rock Ventures IV, L.P.
Stock symbol: TNGX
Transactions as of: Oct 23, 2025
Transactions value $: -$4,846,575
Form type: 4
Date filed: 10/27/2025, 04:15 PM
Previous filing: Sep 29, 2025
Next filing: Nov 5, 2025
SEC: View on sec.gov

Reporting Owners (3)

Name	Relationship	Address	Signature	Signature date	CIK
Third Rock Ventures IV, L.P.	10%+ Owner	C/O THIRD ROCK VENTURES, LLC, 201 BROOKLINE AVE, SUITE 1401, BOSTON	/s/ Kevin Gillis, Chief Operating Officer of TRV GP IV, LLC, general partner of Third Rock Ventures GP IV, L.P., general partner of Third Rock Ventures IV, L.P.	2025-10-27	0001688327
Third Rock Ventures GP IV, L.P.	10%+ Owner	201 BROOKLINE AVE, SUITE 1401, BOSTON	/s/ Kevin Gillis, Chief Operating Officer of TRV GP IV, LLC, general partner of Third Rock Ventures GP IV, L.P.	2025-10-27	0001688326
TRV GP IV, LLC	10%+ Owner	201 BROOKLINE AVE, SUITE 1401, BOSTON	/s/ Kevin Gillis, Chief Operating Officer of TRV GP IV, LLC	2025-10-27	0001688325

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	TNGX	Common Stock	Sale	-$4.85M	-477K	-3.44%	$10.15	13.4M	Oct 23, 2025	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.00 to $10.65, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).
F2	These shares are directly held by Third Rock Ventures IV, L.P. ("TRV IV"). The general partner of TRV IV is Third Rock Ventures GP IV, L.P. ("TRV GP IV"). The general partner of TRV GP IV is TRV GP IV, LLC ("TRV GP IV LLC"). Each of TRV GP IV and TRV GP IV LLC disclaims beneficial ownership of the shares except to the extent of its pecuniary interest therein, if any, and this report shall not be deemed an admission that it is the beneficial owner of such shares.

Content

The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.00 to $10.65, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).

These shares are directly held by Third Rock Ventures IV, L.P. ("TRV IV"). The general partner of TRV IV is Third Rock Ventures GP IV, L.P. ("TRV GP IV"). The general partner of TRV GP IV is TRV GP IV, LLC ("TRV GP IV LLC"). Each of TRV GP IV and TRV GP IV LLC disclaims beneficial ownership of the shares except to the extent of its pecuniary interest therein, if any, and this report shall not be deemed an admission that it is the beneficial owner of such shares.