| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Hoppenot Herve | Director | C/O BICYCLE THERAPEUTICS PLC, BLOCKS A & B, PORTWAY BUILDING, CAMBRIDGE, UNITED KINGDOM | /s/ Travis Thompson, Attorney-in-Fact | 2025-09-10 | 0001596492 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | BCYC | Ordinary Shares | Award | $0 | +12.5K | $0.00 | 12.5K | Sep 8, 2025 | Direct | F1, F2 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | BCYC | Stock Option (right to buy) | Award | $0 | +25K | $0.00 | 25K | Sep 8, 2025 | Ordinary Shares | 25K | $7.16 | Direct | F3 |
| Id | Content |
|---|---|
| F1 | Represents a restricted share unit ("RSU") award. The RSUs will vest in three equal installments on each of September 8, 2026, September 8, 2027 and September 8, 2028. |
| F2 | Each RSU represents a contingent right to receive one ordinary share. |
| F3 | This option will vest in three equal installments on each of September 8, 2026, September 8, 2027 and September 8, 2028. |