Insider Transactions Reported by 25 Insiders of BICYCLE THERAPEUTICS PLC

Insiders trading volume in the past year

	Insiders	Shares	%	Avg Price	Total $
Buys	0
Sells	7	-82,144	100%	$7.10	-$582,995
Net	-7	-82,144	-100%		-$582,995

Name	Relationship	Holdings Value	Past Year Net Change	Change %	Report Date
BAKER BROS. ADVISORS LP	Director, 10%+ Owner	$153,412,999			02 Jan 2026
Kate Bingham	Director	$32,731,633			13 Jul 2021
Gregory Paul Winter	Director	$4,639,528			02 Jan 2026
Kevin Lee	CHIEF EXECUTIVE OFFICER, Director	$3,998,714	-$270,829	-6.3%	02 Jan 2026
Nicholas Keen	Chief Scientific Officer	$1,355,631			03 Jul 2024
Michael Skynner	Chief Technology Officer	$1,046,300	-$84,280	-7.5%	02 Jan 2026
Santiago Arroyo	Chief Development Officer	$973,013			02 Jan 2025
Alistair Milnes	Chief Operating Officer	$883,191	-$94,171	-9.6%	02 Jan 2026
Nigel Crockett	Chief Business Officer	$753,032			02 Jan 2025
Pierre Legault	Director	$690,000			02 Jan 2025
Dominic Smethurst	Chief Medical Officer	$642,233			03 Jan 2023
Michael Charles Ferguson Hannay	Chief Prod & Supply Chain Off	$631,506	-$51,507	-7.5%	02 Jan 2026
Richard N. Kender	Director	$570,860			02 Jan 2025
Janice Bourque	Director	$570,860			02 Jan 2026
Jose-Carlos Gutierrez-Ramos	Director	$570,860			02 Jan 2026
Alethia Young	Chief Financial Officer	$569,509	-$57,762	-9.2%	02 Jan 2026
Lee Kalowski	President and CFO	$530,408			03 Apr 2023
Stephen H. Sands	Director	$431,694			02 Jan 2026
Travis Thompson	Chief Financial Officer	$427,409	-$23,574	-5.2%	03 Feb 2026
Veronica GH Jordan	Director	$293,125			02 Jan 2024
Alessandro Riva	Director	$187,500			02 Jan 2026
Robert Charles Swanton	Director	$132,413	-$872	-0.65%	02 Jan 2026
ROGER D. DANSEY	Director	$107,500			02 Jan 2026
Herve Hoppenot	Director	$107,500			02 Jan 2026
Eric Westin	Chief Medical Officer	$34,575			25 Mar 2025

Insider	Symbol	Class	Transaction	%	Value $	* Price $	Shares	Shares Owned	Date	Ownership

* An asterisk sign (*) next to the price indicates that the price is likely invalid.