| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Bourque Janice | Director | C/O BICYCLE THERAPEUTICS PLC, BLOCKS A & B, PORTWAY BUILDING, CAMBRIDGE, UNITED KINGDOM | /s/ Travis Thompson, Attorney-in-Fact | 06 Jan 2026 | 0001783330 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | BCYC | Ordinary Shares | Award | $0 | +9,500 | +41% | $0.000000 | 32,500 | 02 Jan 2026 | Direct | F1, F2 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | BCYC | Stock Option (right to buy) | Award | $0 | +19,000 | $0.000000 | 19,000 | 02 Jan 2026 | Ordinary Shares | 19,000 | $7.08 | Direct | F3 |
| Id | Content |
|---|---|
| F1 | Represents a restricted share unit ("RSU") award. The RSUs shall vest in four equal installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026. |
| F2 | Each RSU represents a contingent right to receive one ordinary share. |
| F3 | This option shall vest in four equal installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026. |