| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 4.6% | 1,420,300 | 0 | 1,420,300 | /s/ Carl L. Gordon | Carl L. Gordon/Member | |
| ORBIMED CAPITAL LLC | 5.3% | 1,639,700 | 1,639,700 | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member |