| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 14% | $13,205,481 | 4,165,767 | JANUS HENDERSON GROUP PLC | 29 Aug 2025 | |||
| Nantahala Capital Management, LLC | 10% | 0% | $11,130,679 | +$1,227,226 | 3,185,564 | +12% | Nantahala Capital Management, LLC | 30 Sep 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 10% | $6,353,707 | 3,084,324 | BVF PARTNERS L P/IL | 31 Dec 2024 | |||
| STEMPOINT CAPITAL LP | 8.2% | $4,796,694 | 2,328,492 | StemPoint Capital LP | 31 Dec 2024 | |||
| GREAT POINT PARTNERS LLC | 6.3% | -4.4% | $7,183,290 | 2,055,834 | 0% | Great Point Partners, LLC | 30 Sep 2025 | |
| VANGUARD GROUP INC | 5.5% | $5,799,733 | 1,687,735 | The Vanguard Group | 30 Sep 2025 | |||
| ORBIMED ADVISORS LLC | 5.3% | $5,729,276 | 1,639,700 | ORBIMED CAPITAL LLC | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 13% | 4,165,767 | 0.01% | $14,746,815 | |
| ORBIMED ADVISORS LLC | 9.6% | 3,060,000 | 0.26% | $10,863,000 | |
| TCG Crossover Management, LLC | 8.4% | 2,676,580 | 0% | 0.47% | $9,501,859 |
| STEMPOINT CAPITAL LP | 7.8% | 2,488,685 | +39% | 1.6% | $7,749,263 |
| Nantahala Capital Management, LLC | 6.2% | 1,978,492 | 0% | 0.43% | $7,023,647 |
| VANGUARD GROUP INC | 5.3% | 1,687,735 | -4.1% | 0% | $5,991,460 |
| Commodore Capital LP | 4.9% | 1,575,000 | 0% | 0.27% | $5,591,250 |
| Ikarian Capital, LLC | 1.9% | 620,869 | +3.2% | 0.5% | $2,204,084 |
| Soleus Capital Management, L.P. | 1.7% | 550,000 | 0.1% | $1,952,500 | |
| BlackRock, Inc. | 1.3% | 423,128 | +1.5% | 0% | $1,502,105 |
| RENAISSANCE TECHNOLOGIES LLC | 1.3% | 422,012 | +942% | 0% | $1,498,143 |
| DIADEMA PARTNERS LP | 1.1% | 349,789 | -13% | 0.86% | $1,241,751 |
| JANE STREET GROUP, LLC | 0.95% | 302,683 | +218% | 0% | $1,074,525 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.94% | 298,280 | +9.3% | 0% | $1,059,256 |
| TWO SIGMA INVESTMENTS, LP | 0.91% | 289,409 | +224% | 0% | $1,027,402 |
| JPMORGAN CHASE & CO | 0.85% | 271,825 | -64% | 0% | $964,979 |
| Almitas Capital LLC | 0.82% | 261,399 | 0% | 0.21% | $927,966 |
| AdvisorShares Investments LLC | 0.65% | 206,998 | +1.9% | 0.12% | $734,843 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.62% | 197,024 | +11% | 0.02% | $699,435 |
| TWO SIGMA ADVISERS, LP | 0.49% | 157,032 | +508% | 0% | $557,464 |
| BML Capital Management, LLC | 0.47% | 150,000 | 0% | 0.49% | $532,500 |
| CITADEL ADVISORS LLC | 0.38% | 122,062 | 0% | $433,320 | |
| ADAR1 Capital Management, LLC | 0.35% | 113,062 | -73% | 0.04% | $401,370 |
| STATE STREET CORP | 0.3% | 96,858 | 0% | 0% | $343,846 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.27% | 85,594 | -26% | 0% | $303,859 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 23,364,193 | $81,815,600 | +$30,638,554 | $3.55 | 58 |
| 2025 Q2 | 14,875,235 | $29,750,933 | -$917,939 | $2.00 | 50 |
| 2025 Q1 | 15,325,061 | $38,287,272 | +$856,837 | $2.50 | 47 |
| 2024 Q4 | 14,903,856 | $43,958,426 | -$1,103,423 | $2.95 | 54 |
| 2024 Q3 | 14,643,797 | $44,079,533 | +$4,636,496 | $3.01 | 47 |
| 2024 Q2 | 13,044,677 | $45,399,902 | -$5,789,215 | $3.48 | 42 |
| 2024 Q1 | 14,613,555 | $76,690,483 | -$1,507,857 | $5.28 | 41 |
| 2023 Q4 | 14,894,924 | $76,148,127 | +$50,529,562 | $5.14 | 44 |
| 2023 Q3 | 3,003,814 | $15,739,243 | +$10,118,087 | $5.24 | 34 |
| 2023 Q2 | 965,701 | $1,806,003 | +$1,806,005 | $1.87 | 28 |