HBM Healthcare Investments (Cayman) Ltd. - 31 Dec 2024 SCHEDULE 13G Report for Upstream Bio, Inc. Common Stock, par value $0.001 per share (UPB)

Filing Manager: HBM Healthcare Investments (Cayman) Ltd.
Reporting Manager: HBM Healthcare Investments (Cayman) Ltd.
Security: Upstream Bio, Inc. Common Stock, par value $0.001 per share
Symbol: UPB
Shares outstanding: 53,236,392 shares
Disclosed Ownership: 2,715,056 shares
Ownership: 5.1%
Form type: SCHEDULE 13G
Filing time: 13 Feb 2025, 16:16:17 UTC
Date of event: 31 Dec 2024
Next filing: 14 Nov 2025
SEC: View on sec.gov

Reporting Managers (1)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
HBM Healthcare Investments (Cayman) Ltd.	5.1%	2,715,056	2,715,056	0	/s/ Jean-Marc LeSieur	Jean-Marc LeSieur, Managing Director