| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 4.89% | 2.39M | 2.39M | 0 | /s/ Nicholas Farren | Nicholas Farren - Chief Operating Officer | |
| Polar Capital LLP | 4.89% | 2.39M | 2.39M | 0 | /s/ Nicholas Farren | Nicholas Farren - Chief Operating Officer | |
| Polar Capital Funds PLC - Biotechnology Fund | 4.89% | 2.39M | 2.39M | 0 | /s/ Nicholas Farren | Nicholas Farren - Chief Operating Officer |