| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 11% | 25,600,210 | 0 | 25,600,210 | Kristin Mariani | Head of North America Compliance, CCO | |
| Janus Henderson Biotech Innovation Master Fund Ltd | 8.6% | 2,193,481 | 0 | 2,193,481 | Kristin Mariani | Head of North America Compliance, CCO |