Opaleye Management Inc. - Oct 10, 2025 SCHEDULE 13G Report for Karyopharm Therapeutics Inc. Common Stock, no par value (KPTI)

Filing Manager: Opaleye Management Inc.
Reporting Manager: Opaleye Management Inc.
Security: Karyopharm Therapeutics Inc. Common Stock, no par value
Symbol: KPTI
Shares outstanding: 16.6M shares
Disclosed Ownership: 1.57M shares
Ownership: 9.48%
Form type: SCHEDULE 13G
Date filed: 10/17/2025, 04:05 PM
Date of event: Oct 10, 2025
SEC: View on sec.gov

Reporting Managers (3)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
Opaleye Management Inc.	9.48%	1.57M	0	1.57M	/s/ James Silverman	President
Opaleye, L.P.	9.48%	1.57M	0	1.57M	/s/ James Silverman	General Partner
James Silverman	9.48%	1.57M	0	1.57M	/s/ James Silverman	Individually